When HbA1c and Blood Glucose Do Not Match: How Much Is Determined by Race, by Genetics, by Differences in Mean Red Blood Cell Age?
Open accessAbstract
Commentary placing genetic ancestry markers and racial difference in HbA1c in the context of more common variations in the HbA1c-average glucose relationship and their clinical implications.
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Using the standardized report, clinicians can address glucose variability or use GMI to discuss discrepancies between CGM-derived glucose exposure and laboratory-measured A1C.
“Using the standardized report the clinician can also address glucose variability (e.g., %CV metric) (75) or use glucose management indicator (GMI) metric (43) to discuss the possible discrepancies noted in glucose exposure derived from CGM data versus the individual's laboratory-measured A1C (40; 76).”
From Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range (2019) · cites this paper as [76]
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References 18 · Cited by 36
- Authors
- Cohen, R. M., Franco, R. S., Smith, E. P., & Higgins, J. M.
- Affiliations
- Cincinnati VA Medical Center (US)
- University of Cincinnati (US)
- Harvard University (US)
- Corresponding author
- Cohen, Robert M
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2018-11-15
- Volume
- 104
- Issue
- 3
- Pages
- 707-710
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2900481204
- Cited by
- 36
- References
- 18
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 7 · 2020: 8 · 2019: 7
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- University of Cincinnati
- College of Medicine, University of Cincinnati
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Keywords
- HbA1c, blood glucose, genetic ancestry, racial differences, red blood cell age, hemoglobin variants, diabetes mellitus
- MeSH terms
- Biological Variation, Population, Blood Glucose, Diabetes Mellitus, Erythrocytes, Glycated Hemoglobin, Humans, Racial Groups
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