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Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man
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Glucagon-like peptide-1 receptor agonism produces a direct effect to promote urinary sodium excretion, independent of changes in adipose tissue volume.
“However, in the case of tirzepatide, it is noteworthy that glucagon-like peptide-1 receptor agonism produces a direct effect itself to promote urinary sodium excretion, independent of changes in adipose tissue volume38,39.”
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Cites
Physiology of Local Renin-Angiotensin Systems
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Cited by
Sorted by citations
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
Self-citationBorlaug, B. A., Zile, M. R., Kramer, C. M., Baum, S. J., Hurt, K., Litwin, S. E., Murakami, M., Ou, Y., Upadhyay, N., & Packer, M. (2025) · Nature Medicine · doi:10.1038/s41591-024-03374-z · Cited by 166
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management
Holst, J. J. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01113-9 · Cited by 125
Self-citationAndersen, D. B., Grunddal, K. V., Pedersen, J., Kuhre, R. E., Lund, M. L., Holst, J. J., & Ørskov, C. (2021) · Endocrinology · doi:10.1210/endocr/bqaa246 · Cited by 54
Self-citationActivation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree
Bjørnholm, K. D., Ougaard, M. E., Skovsted, G. F., Knudsen, L. B., & Pyke, C. (2021) · Endocrinology, Diabetes & Metabolism · doi:10.1002/edm2.234 · Cited by 16
Metadata
- Authors
- Asmar, A., Cramon, P. K., Simonsen, L., Asmar, M., Sorensen, C. M., Madsbad, S., Moro, C., Hartmann, B., Jensen, B. L., Holst, J. J., & Bülow, J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2019-03-05
- Volume
- 104
- Issue
- 7
- Pages
- 2509-2519
- ISSN
- 0021-972X
- 1945-7197
- Cited by
- 56
- References
- 8
- Language
- en
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