The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A potential novel mechanism for precocious puberty in juvenile hypothyroidism
Abstract
Some children with juvenile hypothyroidism exhibit unexplained precocious puberty. Interaction of TSH with the human FSH receptor (hFSH-R) is a possible pathophysiological mechanism for this syndrome that has not been explored due to the lack of hFSH-free TSH preparations and the scarcity of a suitable hFSH-R-based assay system. To devise an in vitro FSH bioassay suitable for exploring this mechanism, we expressed hFSH-R complementary DNA in COS-7 cells and stimulated them with recombinant hTSH (rec-hTSH). Rec-hTSH elicited a dose-dependent cAMP response in the in vitro hFSH-R bioassay; however, the concentration of rec-hTSH required for half-maximal stimulation was several logs greater than that of hFSH. Rec-hTSH acted as a competitive inhibitor of hFSH at the hFSH-R, indicating that hTSH and hFSH are acting through the same receptor, namely the hFSH-R. This provides a potential novel mechanism for the precocious puberty of juvenile hypothyroidism.
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Cites
Mendelson, C., Dufau, M., & Catt, K. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40746-1 · Cited by 414
Wyk, J. J. V., & Grumbach, M. M. (1960) · The Journal of Pediatrics · doi:10.1016/s0022-3476(60)80250-8 · Cited by 386
COOKE, P. S., & MEISAMI, E. (1991) · Endocrinology · doi:10.1210/endo-129-1-237 · Cited by 204
THOTAKURA, N. R., Desai, R. K., Bates, L., Cole, E. S., Pratt, B. M., & Weintraub, B. D. (1991) · Endocrinology · doi:10.1210/endo-128-1-341 · Cited by 135
Tilly, J. L., Aihara, T., Nishimori, K., Jia, X., Billig, H., Kowalski, K. I., Perlas, E., & Hsueh, A. J. W. (1992) · Endocrinology · doi:10.1210/en.131.2.799 · Cited by 132
CASE OF PRECOCIOUS PUBERTY IN A FEMALE CRETIN
Kendle, F. W. (1905) · BMJ · doi:10.1136/bmj.1.2301.246 · Cited by 77
Hypothalamic-pituitary gonadal axis in boys with primary hypothyroidism and macroorchidism
Castro-Magaña, M., Angulo, M., Canas, J. A., Sharp, A., & Fuentes, B. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80319-6 · Cited by 64
Precocious puberty in juvenile hypothyroidism
Hemady, Z. S., Siler-Khodr, T. M., & Najjar, S. S. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80070-5 · Cited by 58
Kraiem, Z., Sadeh, O., Blithe, D., & Nisula, B. C. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045981 · Cited by 51
Cited by
Thyrotropic Action of Human Chorionic Gonadotropin
YOSHIMURA, M., & HERSHMAN, J. M. (1995) · Thyroid · doi:10.1089/thy.1995.5.425 · Cited by 358
Léger, J. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-0777 · Cited by 72
Migliano, A. B., Romero, I. G., Metspalu, M., Leavesley, M., Pagani, L., Antao, T., Huang, D.-W., Sherman, B. T., Siddle, K., Scholes, C., et al. (2013) · Human Biology · doi:10.1353/hub.2013.a530634 · Cited by 23
Hassani, Y., Larroque, B., Dos Santos, S., Ecosse, E., Bouyer, J., & Léger, J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3286 · Cited by 22
Multicystic ovaries and pituitary pseudo-adenoma associated with primary hypothyroidism
Katulande, P., Kariyawasam, S. S. M., Senanayake, H. M., & Weerakkodi, M. (2013) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2011.565388 · Cited by 12
Metadata
- Authors
- Anasti, J. N.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-01-01
- Volume
- 80
- Issue
- 1
- Pages
- 276-279
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2170116261
- Cited by
- 257
- References
- 9
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
