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Leptin Expression in Human Mammary Epithelial Cells and Breast Milk
Open accessAbstract
Leptin has recently been shown to be produced by the human placenta and potentially plays a role in fetal and neonatal growth. Many functions of the placenta are replaced by the mammary gland in terms of providing critical growth factors for the newborn. In this study, we show that leptin is produced by human mammary epithelial cells as revealed by RT/PCR analysis of total RNA from mammary gland and immunohistochemical staining of breast tissue, cultured mammary epithelial cells, and secretory epithelial cells present in human milk. We also verify that immunoreactive leptin is present in whole milk at 30- to 150-fold higher concentrations than skim milk. We propose that leptin is secreted by mammary epithelial cells in milk fat globules, which partition into the lipid portion of breast milk.
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Cited by
Leptin and reproduction: a review
Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03010-2 · Cited by 557
Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier
Banks, W. A., Coon, A. B., Robinson, S. M., Moinuddin, A., Shultz, J. M., Nakaoke, R., & Morley, J. E. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1253 · Cited by 512
Obesity, adipocytokines, and insulin resistance in breast cancer
Rose, D. P., Komninou, D., & Stephenson, G. D. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00142.x · Cited by 460
Hu, X. (2002) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/94.22.1704 · Cited by 455
Transport of Milk Constituents by the Mammary Gland
Shennan, D. B., & Peaker, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.925 · Cited by 411
Metadata
- Authors
- Smith-Kirwin, S. M.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-05-01
- Volume
- 83
- Issue
- 5
- Pages
- 1810-1810
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2167255011
- Cited by
- 426
- References
- 0
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smith-Kirwin, S. M. (1998). Leptin Expression in Human Mammary Epithelial Cells and Breast Milk. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.83.5.1810
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
