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Cited by 1,743Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGestational Diabetes Research and Management

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women

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Legro, R. S.·1999·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.84.1.165
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Abstract

Women with polycystic ovary syndrome (PCOS) are insulin resistant, have insulin secretory defects, and are at high risk for glucose intolerance. We performed this study to determine the prevalence of glucose intolerance and parameters associated with risk for this in PCOS women. Two-hundred and fifty-four PCOS women, aged 14-44 yr, were prospectively evaluated at 2 centers, 1 urban and ethnically diverse (n = 110) and 1 rural and ethnically homogeneous (n = 144). The rural PCOS women were compared to 80 control women of similar weight, ethnicity, and age. A 75-g oral glucose challenge was administered after a 3-day 300-g carbohydrate diet and an overnight fast with 0 and 2 h blood samples for glucose levels. Diabetes was categorized according to WHO criteria. The prevalence of glucose intolerance was 31.1% impaired glucose intolerance (IGT) and 7.5% diabetes. In nonobese PCOS women (body mass index, <27 kg/m2), 10.3% IGT and 1.5% diabetes were found. The prevalence of glucose intolerance was significantly higher in PCOS vs. control women (chi2 = 7.0; P = 0.01; odds ratio = 2.76; 95% confidence interval = 1.23-6.57). Variables most associated with postchallenge glucose levels were fasting glucose levels (P < 0.0001), PCOS status (P = 0.002), waist/hip ratio (P = 0.01), and body mass index (P = 0.021). The American Diabetes Association criteria applied to fasting glucose significantly underdiagnosed diabetes compared to the WHO criteria (3.2% vs. 7.5%; chi2 = 4.7; P = 0.046; odds ratio = 2.48; 95% confidence interval = 1.01-6.69). We conclude that 1) PCOS women are at significantly increased risk for IGT and type 2 diabetes mellitus at all weights and at a young age; 2) these prevalence rates are similar in 2 different populations of PCOS women, suggesting that PCOS may be a more important risk factor than ethnicity or race for glucose intolerance in young women; and 3) the American Diabetes Association diabetes diagnostic criteria failed to detect a significant number of PCOS women with diabetes by postchallenge glucose values.

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Metadata

Authors
Legro, R. S.
Affiliations
Pennsylvania State University (US)
ORCID
Legro, R. S.
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1999-01-01
Volume
84
Issue
1
Pages
165-169
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.84.1.165
OpenAlex
W2096126402
Cited by
1,743
References
0
Citations by year
2026: 16 · 2025: 25 · 2024: 36 · 2023: 24 · 2022: 50 · 2021: 64 · 2020: 54 · 2019: 42 · 2018: 43 · 2017: 66 · 2016: 59 · 2015: 88 · 2014: 81 · 2013: 73 · 2012: 84
FWCI
44.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040605)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08 HD-O118, U54HD034449)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
polycystic ovary syndrome, type 2 diabetes, impaired glucose tolerance, insulin resistance, insulin secretion, diabetes risk factors, prevalence, fasting blood glucose, waist-to-hip ratio, body mass index, ethnic differences, diagnostic criteria, underdiagnosis, oral glucose tolerance test, young women, obesity
MeSH terms
Adolescent, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Risk, Body Mass Index, Prevalence

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