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Cited by 381Hormonal and reproductive studiesAdrenal Hormones and DisordersHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Pharmacokinetics, Efficacy, and Safety of a Permeation-Enhanced Testosterone Transdermal System in Comparison with Bi-Weekly Injections of Testosterone Enanthate for the Treatment of Hypogonadal Men

Dobs, A. S.·1999·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.84.10.3469
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Abstract

The pharmacokinetics, efficacy, and safety of the Androderm testosterone (T) transdermal system (TTD) and intramuscular T enanthate injections (IM) for the treatment of male hypogonadism were compared in a 24-week multicenter, randomized, parallel-group study.Sixty-six adult hypogonadal men (22-65 years of age) were withdrawn from prior IM treatment for 4 -6 weeks and then randomly assigned to treatment with TTD (two 2.5-mg systems applied nightly) or IM (200 mg injected every 2 weeks); there were 33 patients per group.Twenty-six patients in the TTD group and 32 in the IM group completed the study.TTD treatment produced circadian variations in the levels of total T, bioavailable T, dihydrotestosterone, and estradiol within the normal physiological ranges.IM treatment produced supraphysiological levels of T, bioavailable T, and estradiol (but not dihydrotestosterone) for several days after each injection.Mean morning sex hormone levels were within the normal range in greater proportions of TTD patients (range, 77-100%) than IM patients (range, 19 -84%).Both treatments normalized LH levels in approximately 50% of patients with primary hypogonadism; however, LH levels were suppressed to

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Metadata

Authors
Dobs, A. S.
Affiliations
Johns Hopkins University (US)
ORCID
Dobs, A. S.
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1999-10-01
Volume
84
Issue
10
Pages
3469-3478
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.84.10.3469
OpenAlex
W2148714770
Cited by
381
References
32
Citations by year
2026: 5 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 11 · 2015: 22 · 2014: 12 · 2013: 12 · 2012: 21
FWCI
8.06
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of South Florida
  • Svenska Läkaresällskapet
  • National Institutes of Health
  • Medical Research Council
  • National Center for Research Resources (5M01 RR 00722, M01RR000722, RR-0003524)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
testosterone replacement therapy, male hypogonadism, transdermal testosterone, testosterone enanthate, intramuscular injection, pharmacokinetics, sex hormone levels, LH suppression, estradiol, dihydrotestosterone, gynecomastia, hematocrit, skin irritation, sexual function, depression, hypergonadotropic hypogonadism
MeSH terms
Administration, Cutaneous, Adult, Aged, Drug Administration Schedule, Hematocrit, Humans, Hypogonadism, Injections, Intramuscular, Male, Middle Aged, Permeability, Prostate, Testosterone, Treatment Outcome

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