The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth
Open accessAbstract
The risk of adverse perinatal outcome among 8839 women recruited to a multicenter, prospective cohort study was related to maternal circulating concentrations of trophoblast-derived proteins at 8-14 wk gestation. Women with a pregnancy-associated plasma protein A (PAPP-A) in the lowest fifth percentile at 8-14 wk gestation had an increased risk of intrauterine growth restriction [adjusted odds ratio, 2.9; 95% confidence interval (CI), 2.0-4.1], extremely premature delivery (adjusted odds ratio, 2.9; 95% CI, 1.6-5.5), moderately premature delivery (adjusted odds ratio, 2.4; 95% CI, 1.7-3.5), preeclampsia (adjusted odds ratio, 2.3; 95% CI, 1.6-3.3), and stillbirth (adjusted odds ratio, 3.6; 95% CI, 1.2-11.0). The strengths of the associations were similar when the test was performed before 13 wk gestation or between 13 and 14 wk gestation. In contrast, levels of free beta-human CG, another circulating protein synthesized by the syncytiotrophoblast, were not predictive of later outcome in multivariate analysis. PAPP-A has been identified as a protease specific for IGF binding proteins. We conclude that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Lawrence, J. B., Oxvig, C., Overgaard, M. T., Sottrup-Jensen, L., Gleich, G. J., Hays, L. G., Yates, J. R., & Conover, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3149 · Cited by 706
Role of insulin-like growth factor binding proteins in controlling IGF actions
Clemmons, D. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00024-0 · Cited by 392
Effect of Maternal Cigarette Smoking on Pregnancy Complications and Sudden Infant Death Syndrome
DiFranza, J. R., & Lew, R. A. (1995) · European Journal of General Practice · doi:10.3109/13814789509160303 · Cited by 350
Ong, C. Y. T., Liao, A. W., Spencer, K., Munim, S., & Nicolaides, K. H. (2000) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2000.tb11618.x · Cited by 347
First-Trimester Growth and the Risk of Low Birth Weight
Smith, G. C. S., Smith, M. F. S., McNay, M. B., & Fleming, J. E. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199812173392504 · Cited by 311
Self-citationRole of the IGF system in trophoblast invasion and pre-eclampsia
Irwin, J. C., Suen, L.-F., Martina, N. A., Mark, S. P., & Giudice, L. C. (1999) · Human Reproduction · doi:10.1093/humrep/14.suppl_2.90 · Cited by 164
Da, K., Pj, S., Pd, Z., Mb, L., & Sg, G. (1994) · PubMed · Cited by 160
Tul, N., Spencer, K., Noble, P., Chan, C., & Nicolaides, K. H. (1999) · Prenatal Diagnosis · doi:10.1002/(sici)1097-0223(199911)19:11<1065::aid-pd695>3.0.co;2-r · Cited by 140
Gluckman, P. D., & Liggins, G. C. (1984) · Elsevier eBooks · doi:10.1016/b978-0-407-00366-8.50022-8 · Cited by 133
Cited by
Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
Figueras, F., & Gardosi, J. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.055 · Cited by 485
Etiology and prevention of stillbirth
Fretts, R. C. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.03.074 · Cited by 462
Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388
Potential markers of preeclampsia – a review
Grill, S., Rusterholz, C., Zanetti-Dällenbach, R., Tercanli, S., Holzgreve, W., Hahn, S., & Lapaire, O. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-70 · Cited by 293
Smith, G. C., & Fretts, R. C. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61723-1 · Cited by 291
Self-citation
Metadata
- Authors
- Smith, G. C. S.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-04-01
- Volume
- 87
- Issue
- 4
- Pages
- 1762-1767
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2170089141
- Cited by
- 478
- References
- 16
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth. https://app.cochat.ai/papers/10.1210/jc.87.4.1762
- The paper
- Smith, G. C. S. (2002). Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.87.4.1762
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
