AROMATIZATION OF ANDROSTENEDIONE BY THE DIENCEPHALON1
Abstract
Diencephalic tissue containing median eminence and hypothalamus has been dissected from human male fetuses at 10 and 22 weeks. In vitro incubation of homogenates showed conversion of androstenedione-4-14C to estrone and estradiol by these tissues but not by control cerebral cortex. Aromatization by diencephalic tissue is consistent with the thesis that androgens may be converted at the central level and that “androgen” effects may be mediated via aromatized products (estrogens).
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Testosterone is metabolized into estradiol and dihydrotestosterone, which bind ER and AR, and these receptors are critical for organizing many sex differences in the brain and behavior.
“Testosterone is metabolized into two principle ligands: estradiol, which binds to estrogen receptor (ER) and the androgen, dihydrotestosterone, which binds to androgen receptor (AR), 17 and these receptors are critical for organizing many sex differences in the brain and behavior.”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [17]
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Cited by 321
- Authors
- Naftolin, F., Ryan, K. J., & Petro, Z.
- Affiliations
- University of California San Diego (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1971-08
- Volume
- 33
- Issue
- 2
- Pages
- 368-370
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2005737804
- Cited by
- 321
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 11 · 2017: 2 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- aromatization, androstenedione, diencephalon, median eminence, hypothalamus, estrone, estradiol, fetal brain, androgen metabolism, estrogen synthesis, human fetal brain
- MeSH terms
- Androstanes, Carbon Isotopes, Cerebral Cortex, Chromatography, Paper, Crystallization, Estradiol, Estrogens, Estrone, Feedback, Female, Fetus, Humans, Hypothalamus, Luteinizing Hormone, Male, Pregnancy, Radioisotope Dilution Technique, 17-Ketosteroids, In Vitro Techniques
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