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VARIATION OF PITUITARY RESPONSIVENESS TO SYNTHETIC LRF DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE
Abstract
Synthetic. LRF (IV 150 μg dose) elicited a prompt increase in circulating LH during all phases of the cycle studied. The maximal response was found during preovulatory phase and the minimal response was seen during the early follicular phase. A change in LRF responsiveness with greater and more sustained LH release from the early to the late follicular phase was observed. The response during luteal phase was significantly greater than responses in both the early and the late follicular phases. A concomitant but a much smaller response in the rise of serum FSH levels was observed. These data indicate that the sensitivity of pituitary gonadotrophs to LRF is preferentially increased for LH release during the late follicular phase of the cycle and that a maximal pituitary responsiveness to LRF appears to occur at the midcycle.
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Citations
Cited by
Santen, R. J., & Bardin, C. W. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107454 · Cited by 706
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
Rebar, R., Judd, H. L., Yen, S. S., Rakoff, J., Vandenberg, G., & Naftolin, F. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108400 · Cited by 622
Self-citationPOLYCYSTIC OVARY SYNDROME: A CHANGING PERSPECTIVE
FRANKS, S. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00457.x · Cited by 526
Muasher, S. J., Oehninger, S., Simonetti, S., Matta, J., Ellis, L. M., Liu, H.-C., Jones, G. S., & Rosenwaks, Z. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60077-8 · Cited by 302
Chan, Y.-M., Butler, J. P., Sidhoum, V. F., Pinnell, N. E., & Seminara, S. B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1282 · Cited by 100
Metadata
- Authors
- Yen, S. S. C., VandenBerg, G., Rebar, R., & Ehara, Y.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1972-12
- Volume
- 35
- Issue
- 6
- Pages
- 931-934
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979304877
- Cited by
- 235
- References
- 0
- FWCI
- 25.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: VARIATION OF PITUITARY RESPONSIVENESS TO SYNTHETIC LRF DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE. https://app.cochat.ai/papers/10.1210/jcem-35-6-931
- The paper
- Yen, S. S. C., VandenBerg, G., Rebar, R., & Ehara, Y. (1972). VARIATION OF PITUITARY RESPONSIVENESS TO SYNTHETIC LRF DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-35-6-931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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