The DOI matches its Crossref record.
Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.
Abstract
The concentrations of testosterone, androstenedione, 17β-estradiol, and estrone were measured in peripheral and ovarian vein sera obtained at the time of surgery from 10 postmenopausal women undergoing bilateral oophorectomy. A higher ovarian than peripheral vein concentration was found for all hormones studied. The differences between ovarian and peripheral vein concentrations were 15-fold for testosterone (3033 ± 1046 pg/ml vs 198 ± 27 pg/ml, p <0.01); 4-fold for androstenedione (3455 ± 1330 pg/ml vs 754 ± 174 pg/ml, NS) and 2-fold for both 17β-estradiol (31.1 ± 6.3 pg/ml vs 14.6 ± 2.9 pg/ml, p < 0.05); and estrone (71.5 ± 13.3 pg/ml vs 30.3 ± 3.4 pg/ml, p < 0.05). It is concluded that the postmenopausal ovary continues to secrete a large amount of testosterone and a moderate amount of androstenedione. The small magnitude of the peripheral and ovarian vein estrogen differences could account for only minimal ovarian estrogen secretion.
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“In fact, the postmenopausal ovary is well known to secrete testosterone, and most authors agree that it also secretes some 4-dione (147, 148).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [147]
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Shumaker, S. A., Legault, C., Rapp, S. R., Thal, L., Wallace, R. B., Ockene, J. K., Hendrix, S. L., Jones III, B. N., Assaf, A. R., Jackson, R. D., et al. (2003) · JAMA · doi:10.1001/jama.289.20.2651 · Cited by 2,178
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Treatment of Postmenopausal Osteoporosis with Transdermal Estrogen
Lufkin, E. G., Wahner, H. W., O’Fallon, W. M., Hodgson, S. F., Kotowicz, M. A., Lane, A. W., Judd, H. L., Caplan, R. H., & Riggs, B. L. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-1-1 · Cited by 813
“Serum estrone, estradiol, and follicle-stimulating hormone levels were measured by radioimmunoassay (15).”
Self-citationRisch, H. A. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.23.1774 · Cited by 771
Burger, H. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02985-0 · Cited by 771
“Concentrations in the ovarian vein of postmenopausal women are considerably higher than those in peripheral blood (10), providing evidence that the postmenopausal ovary is primarily an androgen-secreting organ.”
Background
Metadata
- Authors
- JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C.
- Affiliations
- University of California San Diego (US)
- University of California, Los Angeles (US)
- ORCID
- LUCAS, WILLIAM E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-12
- Volume
- 39
- Issue
- 6
- Pages
- 1020-1024
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2037753918
- Cited by
- 511
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 2 · 2014: 20 · 2013: 10 · 2012: 9
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- postmenopausal ovary, ovarian hormone secretion, testosterone, androstenedione, estradiol, estrone, peripheral venous blood, oophorectomy, ovarian androgen production, estrogen synthesis
- MeSH terms
- Adult, Aged, Androstenedione, Arm, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Hysterectomy, Luteinizing Hormone, Menopause, Middle Aged, Ovary, Radioimmunoassay, Testosterone, Veins
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