Antiovulatory Activity of Synthetic Corticoids
Abstract
A single dose of triamcinolone acetonide had antiovulatory properties in 7 of 11 women when injected on day 1 or 2 of the menstrual cycle. Daily blood studies in three subjects revealed that the FSH and LH surges were absent, and there was no rise in plasma progesterone. Follicular function, as manifested by estrogen levels, was maintained.
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The study design did not involve randomization because of concerns about possible carryover effects of glucocorticoids into the subsequent menstrual cycle.
“Because of concerns about possible carryover effects of glucocorticoids into the subsequent menstrual cycle [36,37], our study design did not involve randomization”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [36]
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Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1
Saketos, M., Sharma, N., & Santoro, N. F. (1993) · Biology of Reproduction · doi:10.1095/biolreprod49.6.1270 · Cited by 145 · see citing works
High serum cortisol levels in exercise-associated amenorrhea
DING, J.-H., SHECKTER, C. B., DRINKWATER, B. L., SOULES, M. R., & BREMNER, W. J. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-4-530 · Cited by 131 · see citing works
- Authors
- CUNNINGHAM, G. R., CAPERTON, E. M., & GOLDZIEHER, J. W.
- Affiliations
- Texas Biomedical Research Institute (US)
- ORCID
- CUNNINGHAM, G. R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-02
- Volume
- 40
- Issue
- 2
- Pages
- 265-267
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2017081833
- Cited by
- 39
- References
- 0
- Citations by year
- 2026: 1 · 2022: 1 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- triamcinolone acetonide, antiovulatory activity, synthetic corticosteroids, gonadotropin surge, follicle-stimulating hormone, luteinizing hormone, plasma progesterone, follicular function, estrogen, menstrual cycle, ovulation inhibition
- MeSH terms
- Adult, Estrogens, Female, Follicle Stimulating Hormone, Humans, Hydrocortisone, Luteinizing Hormone, Ovulation, Progesterone, Triamcinolone Acetonide
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