Inhibition of Luteinizing Hormone Secretion Induced by Synthetic LRH by Long-term Treatment with Glucocorticoids in Human Subjects
Abstract
The response of luteinizing hormone to a single injection of synthetic LRH was established in 6 women and 7 men following an intramuscular dose of 0.2mg or 0.1mg. Significant increases of serum LH were observed in 30 min. Pretreatment with metyrapone for one day (4.5 g/sugject injection of synthetic LRH (0.1 MG/SUBJECT). Seven women, 21-48 years of age who were treated with prednisolone for a least 11/2 months were examined for responsiveness of the anterior pituitary to a single injection of synthetic LRH (0.2 MG). The secretion of LH was markedly suppressed and maximal serum levels of LH WERE OBSERVED 90 MIN FOLLOWING LRH injection.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
Cited by 261
- Authors
- SAKAKURA, M., TAKEBE, K., & NAKAGAWA, S.
- Affiliations
- Hokkaido University (JP)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1975-05
- Volume
- 40
- Issue
- 5
- Pages
- 774-779
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2098389360
- Cited by
- 261
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 2
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- luteinizing hormone secretion, gonadotropin-releasing hormone, glucocorticoids, prednisolone, metyrapone, LH suppression
- MeSH terms
- Adult, Female, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Metyrapone, Pituitary Gland, Prednisolone, Sex Factors, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
