Reversible gonadotropin Deficiency in Male Cushing's Dusease
Abstract
Twelve adult males with documented active Cushing's disease were studied. Mean plasma testosterone (T) was significantly decreased: 1.8 +/- 0.3 (SEM) ng/ml (N=6.8 +/- 0.5); gonadotropin measurements in 8 patients, in basal conditions and under LH-RH iv, showed a significant decrease in both FSH and LH. A further study of 11 patients in remission of Cushing's disease indicated a significant increase in plasma T and gonadotropins up to the normal range. One patient with an initial low T value had a normalized T while in remission, then a dramatic decrease when the disease relapsed. We conclude: a hypogonadotropic hypogonadism is found in male Cushing's disease; it disappears as early as hypercortisolism is suppressed. Some possible mechanisms are discussed.
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In patients with Cushing's syndrome, long-term hypercortisolemia has been associated with decreased LH and FSH concentrations and hypogonadotropic amenorrhea, irrespective of coexistent hyperandrogenemia.
“In patients with Cushing's syndrome, long-term hypercortisolemia has been associated with decreased LH and FSH concentrations and hypogonadotropic amenorrhea, irrespective of coexistent hyperandrogenemia [18,19].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [19]
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References 16 · Cited by 202
- Authors
- LUTON, J.-P., THIEBLOT, P., VALCKE, J.-C., MAHOUDEAU, J. A., & BRICAIRE, H.
- Affiliations
- Hôpital Cochin (FR)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-09
- Volume
- 45
- Issue
- 3
- Pages
- 488-495
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2131129268
- Cited by
- 202
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 6 · 2016: 6 · 2015: 6 · 2013: 5 · 2012: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- Cushing's disease, male hypogonadism, hypogonadotropic hypogonadism, gonadotropin deficiency, testosterone, follicle-stimulating hormone, luteinizing hormone, LH-RH stimulation, hypercortisolism, remission, recurrence
- MeSH terms
- Adolescent, Adrenocorticotropic Hormone, Adult, Cushing Syndrome, Follicle Stimulating Hormone, Chorionic Gonadotropin, Gonadotropins, Pituitary, Humans, Hydrocortisone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Middle Aged, Mitotane, Testosterone
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