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PREGNANCIES FOLLOWING CHRONIC INTERMITTENT (PULSATILE) ADMINISTRATION OF Gn-RH BY MEANS OF A PORTABLE PUMP (“ZYKLOMAT”) - A NEW APPROACH TO THE TREATMENT OF INFERTILITY IN HYPOTHALAMIC AMENORRHEA
Abstract
In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.
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Citations
Cited by
Sexual Dimorphism in the Control of Growth Hormone Secretion*
JANSSON, J.-O., EDÉN, S., & ISAKSSON, O. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-2-128 · Cited by 745
Clinical Management of Congenital Hypogonadotropic Hypogonadism
Young, J., Xu, C., Papadakis, G. E., Acierno, J. S., Maione, L., Hietamäki, J., Raivio, T., & Pitteloud, N. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00116 · Cited by 396
BÄCKSTRÖM, C. T., McNEILLY, A. S., LEASK, R. M., & BAIRD, D. T. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb02631.x · Cited by 344
The Hypothalamic Control of the Menstrual Cycle and the Role of Endogenous Opioid Peptides
FERIN, M., VAN VUGT, D., & WARDLAW, S. (1984) · Proceedings of the 1983 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571140-1.50015-3 · Cited by 311
A Model Based on Receptor Desensitization for Cyclic AMP Signaling in Dictyostelium Cells
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Metadata
- Authors
- LEYENDECKER, G., WILDT, L., & HANSMANN, M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1980-11
- Volume
- 51
- Issue
- 5
- Pages
- 1214-1216
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2015712188
- Cited by
- 310
- References
- 0
- FWCI
- 16.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PREGNANCIES FOLLOWING CHRONIC INTERMITTENT (PULSATILE) ADMINISTRATION OF Gn-RH BY MEANS OF A PORTABLE PUMP (“ZYKLOMAT”) - A NEW APPROACH TO THE TREATMENT OF INFERTILITY IN HYPOTHALAMIC AMENORRHEA. https://app.cochat.ai/papers/10.1210/jcem-51-5-1214
- The paper
- LEYENDECKER, G., WILDT, L., & HANSMANN, M. (1980). PREGNANCIES FOLLOWING CHRONIC INTERMITTENT (PULSATILE) ADMINISTRATION OF Gn-RH BY MEANS OF A PORTABLE PUMP (“ZYKLOMAT”) - A NEW APPROACH TO THE TREATMENT OF INFERTILITY IN HYPOTHALAMIC AMENORRHEA. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-51-5-1214
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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