The DOI matches its Crossref record.
IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY
Abstract
Immunoreactive (IR) corticotropin-releasing factor (CRF)-like activity was detectable in the majority of plasma samples obtained from women in the third trimester of pregnancy (68.7 +/- 23.6 pg/ml (14.4 +/- 4.9 fmol/ml); mean +/- SE, n = 15), but not in plasma (less than 10 pg/ml) from first (n = 9) or second (n = 11) trimester of pregnancy, 1 day post partum (n = 7), non-pregnant women (n = 10), or in plasma obtained from patients with Cushing's disease (n = 2) or Nelson's syndrome (n = 1), or in basal (n = 6) or ether-stressed (n = 6) rat plasma. Gel filtration of third trimester pooled plasma revealed that the majority of such material eluted with Kav of rat CRF (1-41). The IR CRF (1-41)-sized material eluted with the identical retention time as rat CRF in a reverse phase high performance liquid chromatography (HPLC) system. The detection of IR CRF exclusively in third trimester maternal plasma, together with our previous demonstration that material physicochemically indistinguishable from it is present in human term placental extracts, suggests that the placenta may be the source of plasma IR CRF.
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Cited by
Yim, I. S., Tanner Stapleton, L. R., Guardino, C. M., Hahn-Holbrook, J., & Dunkel Schetter, C. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-101414-020426 · Cited by 749
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Actions of Placental and Fetal Adrenal Steroid Hormones in Primate Pregnancy*
PEPE, G. J., & ALBRECHT, E. D. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-5-608 · Cited by 498
The hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment
Lindsay, J. R., & Nieman, L. K. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0025 · Cited by 449
Potter, E., Behan, D. P., Fischer, W. H., Linton, E. A., Lowry, P. J., & Vale, W. W. (1991) · Nature · doi:10.1038/349423a0 · Cited by 358
Metadata
- Authors
- ATSUSHI, S., ANTHONY, S. L., MARJORIE, M. L., ANDREW, N. M., TOSHIHIRO, S., & DOROTHY, T. K.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1984-10
- Volume
- 59
- Issue
- 4
- Pages
- 812-814
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2045287102
- Cited by
- 184
- References
- 0
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY. https://app.cochat.ai/papers/10.1210/jcem-59-4-812
- The paper
- ATSUSHI, S., ANTHONY, S. L., MARJORIE, M. L., ANDREW, N. M., TOSHIHIRO, S., & DOROTHY, T. K. (1984). IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-59-4-812
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