The DOI matches its Crossref record.
Progressive Decrease in Serum Sex Hormone-Binding Globulin from Infancy to Late Prepuberty in Boys
Abstract
Serum Sex hormone-binding globulin (SHBG) levels and affinity constant (Ka) of SHBG-dihydrotestosterone association were determined in 91 boys, aged 3 months to 15 yr, all at Tanner stage I of pubertal development. A gradual decrease in serum SHBG as a function of age was found in spite of unchanged serum testosterone levels. Ka values at different ages were not significantly different. Since steroids bound to SHBG are not transported into most tissues, particularly brain, a decrease in SHBG will have the effect of increasing tissue entrance of non-SHBG-bound sex hormones despite unchanged plasma concentrations. We speculate that the gradually increasing androgen and estrogen milieu of the brain created by this mechanism might be of physiological significance in triggering the onset of puberty.
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The pubertal decrease in SHBG is stronger in men, with a twofold decrease.
“During puberty, the concentration of SHBG falls in both sexes, with a stronger twofold decrease in men, resulting in adult men having only half of the SHBG concentration as compared to women of the same age [58, 59].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [58]
During puberty, the concentration of SHBG falls in both sexes.
“During puberty, the concentration of SHBG falls in both sexes, with a stronger twofold decrease in men, resulting in adult men having only half of the SHBG concentration as compared to women of the same age [58, 59].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [58]
Adult men have only half the SHBG concentration compared to women of the same age.
“During puberty, the concentration of SHBG falls in both sexes, with a stronger twofold decrease in men, resulting in adult men having only half of the SHBG concentration as compared to women of the same age [58, 59].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [58]
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Diverse Roles for Sex Hormone-Binding Globulin in Reproduction
Hammond, G. L. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092593 · Cited by 317
Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Metadata
- Authors
- BELGOROSKY, A., & RIVAROLA, M. A.
- ORCID
- BELGOROSKY, ALICIA
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1986-08
- Volume
- 63
- Issue
- 2
- Pages
- 510-512
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082814916
- Cited by
- 42
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kementerian Pendidikan Nasional
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- sex hormone-binding globulin, dihydrotestosterone, affinity constant, puberty onset, androgens, estrogen, prepubertal boys, age-related changes
- MeSH terms
- Adolescent, Aging, Child, Child, Preschool, Humans, Infant, Male, Sex Hormone-Binding Globulin, Testosterone
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