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Bone Formation Rate in Older Normal Women: Concurrent Assessment with Bone Histomorphometry, Calcium Kinetics, and Biochemical Markers*
Abstract
In 12 younger (age, 30-41 yr) and 11 older (age, 55-73 yr) normal women we assessed bone formation rate using multiple methods. Bone formation (mean +/- SE) was higher in the older women than in the younger women, based on measurements of serum bone Gla-protein (1.67 +/- 0.07 vs. 1.14 +/- 0.10 nmol/L; P less than 0.01), serum bone-specific alkaline phosphatase activity (388 +/- 42 vs. 223 +/- 22 nanokatal/L, P less than 0.01), and bone formation rate by histomorphometry of iliac biopsy (31.1 +/- 4.9% vs. 15.1 +/- 2.7%/yr; P less than 0.01), but was similar in the two groups when accretion rates were assessed by calcium kinetics (5.9 +/- 1.0 vs. 7.5 +/- 1.2; P = NS). This latter discrepancy may have been caused by several age-related factors, especially reduced mineralization of completed osteons, and by not correcting for the decrease in total skeletal calcium in the older group. Our data call into question the traditional belief that bone turnover decreases in older women.
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Citations
Cited by
Pathogenesis of bone fragility in women and men
Seeman, E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08706-8 · Cited by 909
Parfitt, A. M., Villanueva, A. R., Foldes, J., & Rao, D. S. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100319 · Cited by 231
Burch, J., Rice, S., Yang, H., Neilson, A., Stirk, L., Francis, R., Holloway, P., Selby, P., & Craig, D. (2014) · Health Technology Assessment · doi:10.3310/hta18110 · Cited by 132
Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism
Brennan-Speranza, T. C., & Conigrave, A. D. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9931-y · Cited by 71
Metadata
- Authors
- EASTELL, R., DELMAS, P. D., HODGSON, S. F., ERIKSEN, E. F., MANN, K. G., & RIGGS, B. L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1988-10
- Volume
- 67
- Issue
- 4
- Pages
- 741-748
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2051548053
- Cited by
- 273
- References
- 0
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Bone Formation Rate in Older Normal Women: Concurrent Assessment with Bone Histomorphometry, Calcium Kinetics, and Biochemical Markers*. https://app.cochat.ai/papers/10.1210/jcem-67-4-741
- The paper
- EASTELL, R., DELMAS, P. D., HODGSON, S. F., ERIKSEN, E. F., MANN, K. G., & RIGGS, B. L. (1988). Bone Formation Rate in Older Normal Women: Concurrent Assessment with Bone Histomorphometry, Calcium Kinetics, and Biochemical Markers*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-67-4-741
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