The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sunlight Regulates the Cutaneous Production of Vitamin D3by Causing Its Photodegradation*
Abstract
Exposure to sunlight initiates the formation of vitamin D3 in skin as the UV B radiation in the solar spectrum causes the photoconversion of 7-dehydrocholesterol to previtamin D3. A heat-induced isomerization then converts previtamin D3 to vitamin D3 over a period of days. A number of irradiation products of vitamin D3 are known to form upon irradiation with high intensity UV radiation, but the effect of subsequent exposures to sunlight on the vitamin D3 formed in skin is not known. To investigate this phenomenon, human skin containing vitamin D3 was exposed to sunlight in Boston. A model system of [3H]vitamin D3 in methanol was also used to study the effects of sunlight on vitamin D3 throughout the year. Vitamin D3 proved to be exquisitely sensitive to sunlight, and once formed in the skin, exposure to sunlight resulted in its rapid photodegradation to a variety of photoproducts, including 5,6-transvitamin D3, suprasterol I, and suprasterol II.
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Cites
Holick, M. F., MacLaughlin, J. A., & Doppelt, S. H. (1981) · Science · doi:10.1126/science.6256855 · Cited by 558
Self-citation
Cited by
Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156
Self-citationSunscreen photoprotection and vitamin D status
Passeron, T., Bouillon, R., Callender, V., Cestari, T., Diepgen, T. L., Green, A. C., van der Pols, J. C., Bernard, B. A., Ly, F., Bernerd, F., et al. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17992 · Cited by 200
Lucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., & van der Leun, J. C. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp90033b · Cited by 158
Vitamin D: In the evolution of human skin colour
Yuen, A. W. C., & Jablonski, N. G. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.08.007 · Cited by 99
Metadata
- Authors
- WEBB, A. R., DECOSTA, B. R., & HOLICK, M. F.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1989-05
- Volume
- 68
- Issue
- 5
- Pages
- 882-887
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2017652491
- Cited by
- 347
- References
- 1
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
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