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Cited by 77Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen.

Metzger, D L, Kerrigan, J R·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.76.5.8496305
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Abstract

Exogenous and endogenous sex steroid hormones influence GH secretion. To test the relative importance of androgens in the enhancement of GH secretion, we administered flutamide (a potent androgen receptor blocker) to six late pubertal males. Blood samples for GH (and LH) were obtained at 10-min intervals for 24-h periods after 3 days of flutamide and during the untreated state. Waveform-specific, multiple-parameter deconvolution analysis was employed to assess secretory and elimination dynamics for GH. Androgen receptor blockade was confirmed by significant increases in 24-h mean LH concentrations and in total 17 beta-estradiol and free testosterone levels in the serum. Mean serum GH concentrations (24-h) also increased (P < 0.001) during androgen receptor blockade (mean +/- SEM, 2.9 +/- 0.3 vs. 1.8 +/- 0.3 micrograms/L); this was associated with an increased (P < 0.001) GH production rate [152 +/- 15 vs. 93 +/- 16 micrograms/liter of distribution volume (Lv)/24 h]. The enhanced GH secretion during flutamide administration was a result of both increased mass of GH released per secretory burst (12.0 +/- 1.4 vs. 8.4 +/- 1.0 micrograms/Lv; P < 0.005) and increased maximal rate of GH secretion (0.39 +/- 0.04 vs. 0.30 +/- 0.03 micrograms/Lv/min; P < 0.05), as well as a small increase in the number of detectable secretory bursts (12 +/- 1 vs. 10 +/- 1/24 h; P < 0.05). There was no significant change in either the serum half-life of GH or in the half-duration of GH secretory bursts…

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Crossref · 10.1210/jcem.76.5.8496305

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Metadata

Authors
Metzger, D. L., & Kerrigan, J. R.
Affiliations
University of Virginia (US)
ORCID
Metzger, D L
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-05
Volume
76
Issue
5
Pages
1147-1152
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.76.5.8496305
OpenAlex
W1967171675
Cited by
77
References
28
Citations by year
2023: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2012: 2
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08hd000926-03)
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK 07642, T32DK007642)
  • National Center for Research Resources (RR 00847, M01RR000847)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-00926)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
growth hormone secretion, flutamide, androgen receptor blockade, delayed puberty, androgens, estrogen, luteinizing hormone, estradiol, testosterone
MeSH terms
Adolescent, Androgen Antagonists, Androgens, Estrogens, Flutamide, Humans, Luteinizing Hormone, Male, Osmolar Concentration, Puberty, Delayed, Regression Analysis, Gonadal Steroid Hormones, Growth Hormone, Body Mass Index, Androgen Receptor Antagonists

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