Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Abstract
Aging in humans is accompanied by a progressive decline in the secretion of the adrenal androgens dehydroepiandrosterone (DHEA) and DHEA sulfate (DS), paralleling that of the GH-insulin-like growth factor-I (GH-IGF-I) axis. Although the functional relationship of the decline of the GH-IGF-I system and catabolism is recognized, the biological role of DHEA in human aging remains undefined. To test the hypothesis that the decline in DHEA may contribute to the shift from anabolism to catabolism associated with aging, we studied the effect of a replacement dose of DHEA in 13 men and 17 women, 40-70 yr of age. A randomized placebo-controlled cross-over trial of nightly oral DHEA administration (50 mg) of 6-month duration was conducted. During each treatment period, concentrations of androgens, lipids, apolipoproteins, IGF-I, IGF-binding protein-1 (IGFBP-1), IGFBP-3, insulin sensitivity, percent body fat, libido, and sense of well-being were measured. A subgroup of men (n = 8) and women (n = 5) underwent 24-h sampling at 20-min intervals for GH determinations. DHEA and DS serum levels were restored to those found in young adults within 2 weeks of DHEA replacement and were sustained throughout the 3 months of the study. A 2-fold increase in serum levels of androgens (androstenedione, testosterone, and dihydrotestosterone) was observed in women, with only a small rise in androstenedione in men. There was no change in circulating levels of sex hormone-binding globulin, estrone, or estr…
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Positive effects of DHEA replacement have been described on psychological well-being, body composition, and bone mineral density in older, normal adults.
“positive effects of DHEA replacement have been described on psychological well-being (6), body composition (7,8), and bone mineral density (BMD) (9) in older, normal adults.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [6]
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References 36 · Cited by 841
- Authors
- Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S.
- Affiliations
- University of California System (US)
- ORCID
- Nolan, J J
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1994-06
- Volume
- 78
- Issue
- 6
- Pages
- 1360-1367
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2130095506
- Cited by
- 841
- References
- 36
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 15 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 14 · 2013: 19 · 2012: 32
- FWCI
- 27.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Southern California
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5r01ag010979-03)
- National Institute on Aging (R0-1-AG-10979-02)
- National Center for Research Resources (MO1 RR00827, M01RR000827)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- dehydroepiandrosterone, DHEA sulfate, aging, testosterone replacement therapy, insulin-like growth factor I, IGF-binding protein-1, IGF binding protein-3, growth hormone, insulin sensitivity, fat mass, well-being, sex differences, lipoproteins, testosterone, androstenedione, sexual desire, sex hormone-binding globulin, anabolism
- MeSH terms
- Adult, Aged, Aging, Apolipoproteins B, Blood Glucose, Carrier Proteins, Cholesterol, Circadian Rhythm, Dehydroepiandrosterone, Double-Blind Method, Female, Humans, Insulin-Like Growth Factor I, Libido, Lipoproteins, HDL, Lipoproteins, LDL, Male, Middle Aged, Placebos, Sex Characteristics, Growth Hormone, Triglycerides, Apolipoprotein A-I, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 1
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