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Decreased insulin sensitivity in prepubertal girls with premature adrenarche and acanthosis nigricans

Oppenheimer, E, Linder, B, DiMartino-Nardi, J·1995·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.80.2.7852529
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Abstract

Benign premature adrenarche (PA) is the term used to refer to girls with the early development of pubic hair before the age of 8 yr and is characterized by mild hyperandrogenism. Hyperandrogenism in adult women is often not as benign and has been associated with insulin resistance, acanthosis nigricans (AN), and the polycystic ovary syndrome. We have seen a group of young girls with PA who have also been found to have AN. The purpose of this study was to determine whether there are any clinical and biochemical differences in those girls with PA with and without AN. Twelve girls with PA were divided into two groups at the time of evaluation: group I, those without AN (n = 5); and group II, those with AN (n = 7). Adrenal androgen levels were determined in all subjects by a 60-min ACTH stimulation test. Insulin sensitivity was measured by the frequently sampled iv glucose tolerance test with tolbutamide and was assessed using the modified minimal model. Mean chronological age, bone age, and weight for length index were similar in the two groups. The baseline and stimulated levels of adrenal androgens were also not significantly different between the two groups. The group I girls (without AN) had an insulin sensitivity index of 6.75 +/- 1.31, which was in the normal prepubertal range. This was significantly different from that in group II (with AN), who had an insulin sensitivity index of 3.69 +/- 1.29. Therefore, many girls with premature adrenarche can have AN and decreased ins…

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Crossref · 10.1210/jcem.80.2.7852529

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  • Premature and exaggerated adrenarche may be associated with insulin resistance, and girls with premature exaggerated adrenarche appear to be at much higher risk of developing the polycystic ovary syndrome as adults, and infants born small for gestational age may be at increased risk.

    “Premature and exaggerated adrenarche may be associated with insulin resistance, and girls with premature exaggerated adrenarche appear to be at much higher risk of developing the polycystic ovary syndrome as adults (characterized by hyperandrogenism, fewer ovulatory cycles, insulin resistance, and hypertriglyceridemia) (729 -731), and infants born small for gestational age may be at increased risk”

    From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [730]

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Authors
Oppenheimer, E., Linder, B., & DiMartino-Nardi, J.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1995-02
Volume
80
Issue
2
Pages
614-618
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/jcem.80.2.7852529
Cited by
8
References
1
Language
en

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