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Cited by 74Pituitary Gland Disorders and TreatmentsNeuroendocrine Tumor Research AdvancesGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Relative sparing of anterior pituitary function in patients with growth hormone-secreting macroadenomas: comparison with nonfunctioning macroadenomas.

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Greenman, Y, Tordjman, K, Kisch, E, Razon, N, Ouaknine, G, Stern, N·1995·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.80.5.7745003
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Abstract

Pre- and postoperative anterior pituitary function was assessed in 26 subjects with nonfunctioning macroadenoma (NFMA) and in 15 acromegalic subjects with macroadenomas. Preoperatively, NFMA patients had a higher prevalence of secondary hypogonadism (78% vs. 40%; P < 0.05), hypothyroidism (23% vs. 0%; P = 0.06), and hypoadrenalism (43% vs. 7%; P = 0.02) compared to individuals with GH-secreting macroadenoma (GHMA). Patients with NFMA also had a higher prevalence of more severe pituitary failure compared with acromegalic patients; 56% of the patients in this group had more than one pituitary hormone axis impaired compared to only 8% in the acromegalic group. These differences could not be accounted for by tumor grade and/or stage. Transsphenoidal pituitary surgery led to a significant improvement in anterior pituitary function in the NFMA group. Nevertheless, the prevalence of pituitary deficiency postoperatively was still significantly greater in NFMA patients than in the acromegalic group (68% vs. 17%, respectively; P < 0.04). The results suggest that anterior pituitary function is better preserved in GHMA than in NFMA and that this difference is independent of tumor size. The mechanism underlying the lower rate of hypopituitarism in acromegalics with macroadenomas remains to be elucidated.

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Crossref · 10.1210/jcem.80.5.7745003

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Metadata

Authors
Greenman, Y., Tordjman, K., Kisch, E., Razon, N., Ouaknine, G., & Stern, N.
Affiliations
Tel Aviv Sourasky Medical Center (IL)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1995-05
Volume
80
Issue
5
Pages
1577-1583
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.80.5.7745003
OpenAlex
W1996393716
Cited by
74
References
14
Citations by year
2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
1.56
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
anterior pituitary function, growth hormone-secreting pituitary adenoma, non-functioning pituitary macroadenoma, acromegaly, hypopituitarism, secondary hypogonadism, hypothyroidism, adrenal insufficiency, transsphenoidal surgery, pituitary hormone deficiency
MeSH terms
Acromegaly, Adenoma, Adult, Female, Humans, Male, Middle Aged, Pituitary Gland, Anterior, Pituitary Neoplasms, Postoperative Period, Growth Hormone

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