Attenuation of postmenopausal high turnover bone loss in patients with hypoparathyroidism
Abstract
To elucidate the role of PTH in postmenopausal bone loss, we studied 33 postmenopausal patients who received total thyroidectomy due to thyroid carcinoma. Among these patients, 13 were patients with hypoparathyroid function (HPf), and 20 retained normal parathyroid function (NPf) after thyroidectomy. Bone mineral density (BMD), the rate of BMD loss, and incidence of spinal deformity as well as varying bone metabolic markers were analyzed in all patients. The age-matched BMD was clearly higher, and the incidence of spinal deformity was significantly lower in HPf than in NPf. The rate of BMD loss in HPf was significantly lower than in NPf during the early postmenopausal period (within 5 yr after menopause; mean +/- SD, -0.567 +/- 3.05% vs. -2.49 +/- 1.86%/yr, P 5 yr after menopause). Bone metabolic markers indicated that an accelerated bone turnover occurred during the early postmenopausal period in NPf, but not in HPf. These results suggest that the hypoparathyroid condition provides protection against age-related bone loss. This is due in part to attenuation of the high turnover bone loss that occurs early in menopause.
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Postsurgical hypoparathyroidism might attenuate high bone turnover resulting in BMD gain in postmenopausal women.
“Several studies have reported that postsurgical hypoparathyroidism might attenuate high bone turnover resulting in BMD gain in postmenopausal women (56,57).”
From Effect of TSH Suppression Therapy on Bone Mineral Density in Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis (2021) · cites this paper as [57]
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References 20 · Cited by 82
- Authors
- Fujiyama, K., Kiriyama, T., Ito, M., Nakata, K., Yamashita, S., Yokoyama, N., & Nagataki, S.
- Affiliations
- Nagasaki University (JP)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-07
- Volume
- 80
- Issue
- 7
- Pages
- 2135-2138
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2066946944
- Cited by
- 82
- References
- 20
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- postmenopausal bone loss, hypoparathyroidism, parathyroid hormone, bone mineral density, bone turnover, thyroidectomy, thyroid cancer, spinal deformity, bone turnover markers, menopause
- MeSH terms
- Adult, Aged, Calcifediol, Calcitriol, Calcium, Female, Humans, Hypoparathyroidism, Middle Aged, Parathyroid Hormone, Phosphates, Spinal Diseases, Thyroid Neoplasms, Thyroidectomy, Thyrotropin, Thyroxine, Time Factors, Triiodothyronine, Bone Density, Osteoporosis, Postmenopausal, Incidence, Postmenopause
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