The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1
Abstract
The estrogen receptor (ER) is a ligand-activated transcription factor that mediates the effects of the steroid hormone 17β-estradiol, in both males and females. Since the isolation and cloning of ER, the consensus has been that only one such receptor exists. The finding of a second subtype of ER (ERβ) has caused considerable excitement amongst endocrinologists. In this article, we present data regarding the genomic structure and chromosomal localization of the human ERβ gene, demonstrating that two independent ER genes do exist in the human. Furthermore, we present data regarding the tissue distribution of human ERβ, showing that this receptor is expressed in multiple tissues. For instance, ERβ is found in developing spermatids of the testis, a finding of potential relevance for the ongoing debate on the effects of environmental estrogens on sperm counts. In addition, we find ERβ in ovarian granulosa cells, indicating that estrogens also participate in the regulation of follicular growth in the human.
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Citations
Cites
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051
Grandien, K. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03716-0 · Cited by 100
Self-citation
Cited by
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
Self-citationEstrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
Self-citationHuman skin pigmentation: Melanocytes modulate skin color in response to stress
Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976
Endocrine regulation of menstruation
Jabbour, H. N., Kelly, R. W., Fraser, H. M., & Critchley, H. O. D. (2006) · Endocrine Reviews · doi:10.1210/er.2004-0021 · Cited by 588
Metadata
- Authors
- Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjöld, M., & Gustafsson, J.-A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-12-01
- Volume
- 82
- Issue
- 12
- Pages
- 4258-4265
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979903836
- Cited by
- 1,074
- References
- 2
- FWCI
- 27.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjöld, M., & Gustafsson, J.-A. (1997). Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.82.12.4470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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