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Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society1
Abstract
The diagnosis and treatment of GH deficiency (GHD) during childhood and adolescence have been the subject of much controversy (1–3). To insure that patients are appropriately identified and treated, the GH Research Society (GRS) convened a workshop, on October 17–21 1999, in Eilat, Israel. The objectives of this workshop were to formulate consensus guidelines for the diagnosis and treatment of children and adolescents with GHD. The GRS invited clinicians and scientists with expertise in the field, representatives from industries involved in the manufacturing of recombinant GH, and representatives from health authorities from a number of countries to attend the workshop. All of them contributed to the consensus guidelines as detailed below. The diagnosis of GHD in childhood is a multifaceted process requiring comprehensive clinical and auxological assessment, combined with biochemical tests of the GH-insulin-like growth factor (IGF) axis and radiological evaluation. GHD may present as an isolated problem or in combination with multiple pituitary hormone deficiency (MPHD). Each component of this process requires criteria, each of which will be considered below.
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In the citing paper
“GHD was required to be diagnosed using a stimulation test, adhering to the cutoff value of <10 μg/L suggested in the Growth Hormone (GH) Research Society guidelines published in 2000.9”
In the citing paper
“Stimulation test thresholds ranging from <5 to <10 μg/L have been suggested as indicative of GHD in children,73,80,81 with the current consensus value listed as <10 μg/L.9”
In the citing paper
“Previous consensus guidelines suggest that a peak stimulated GH concentration <10 μg/L indicates the presence of GHD in children. However, this threshold value does not take into account sex, age, BMI, or the specific stimulation test used.9,81,92”
In the citing paper
“However, GH replacement may also unmask underlying cortisol or thyroid hormone insufficiencies, necessitating close monitoring of the adequacy of glucocorticoid and thyroid hormone replacement following initiation of GH therapy.9,77,81”
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Citations
Cited by
Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr)
Cacciari, E., Milani, S., Balsamo, A., Spada, E., Bona, G., Cavallo, L., Cerutti, F., Gargantini, L., Greggio, N., Tonini, G., et al. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344156 · Cited by 813
Schneider, H. J., Kreitschmann-Andermahr, I., Ghigo, E., Stalla, G. K., & Agha, A. (2007) · JAMA · doi:10.1001/jama.298.12.1429 · Cited by 549
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty
Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., Rogol, A. D., Lovejoy, J. C., Sheffield-Moore, M., Mauras, N., & Bowers, C. Y. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0038 · Cited by 452
Aimaretti, G., Ambrosio, M. R., Di Somma, C., Fusco, A., Cannavò, S., Gasperi, M., Scaroni, C., De Marinis, L., Benvenga, S., Uberti, E. C. D., et al. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02094.x · Cited by 339
Schneider, H. J., Aimaretti, G., Kreitschmann-Andermahr, I., Stalla, G.-K., & Ghigo, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60673-4 · Cited by 336
Metadata
- Authors
- Society, G. R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-11-01
- Volume
- 85
- Issue
- 11
- Pages
- 3990-3993
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W4254451072
- Cited by
- 349
- References
- 0
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society1. https://app.cochat.ai/papers/10.1210/jcem.85.11.6984
- The paper
- Society, G. R. (2000). Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.85.11.6984
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
