Decrease of Free Thyroxine Levels after Controlled Ovarian Hyperstimulation1
Open accessAbstract
Controlled ovarian hyperstimulation could lead to opposing effects on thyroid function. Therefore, in a prospective study of 65 women undergoing controlled ovarian hyperstimulation, thyroid hormones, T4-binding globulin, TPO antibodies, gonadotropins, estradiol, and PRL were measured before and after controlled ovarian hyperstimulation. After ovarian stimulation (mean ± se of mean): free T4 decreased, 14.4 ± 0.2 vs. 12.9 ± 0.2 pmol/L (P < 0.0001); thyroid-stimulating hormone increased, 2.3 ± 0.3 vs. 3.0 ± 0.4 mU/L (P < 0.0001); T4-binding globulin increased, 25.2 ± 0.7 vs. 33.9 ± 0.9 mg/L (P < 0.0001); total T4 increased, 98.1 ± 2.3 vs. 114.6 ± 2.5 nmol/L (P < 0.0001); total T3 increased, 2.0 ± 0.04 vs. 2.3 ± 0.07 nmol/L (P < 0.0001); TPO antibodies decreased, 370 ± 233 U/mL vs. 355 ± 224 U/mL (P < 0.0001); LH decreased, 8.1 ± 1.1 vs. 0.4 ± 0.1 U/L (P < 0.0001); FSH did not change, 6.5± 0.6 vs. 7.9 ± 0.9 U/L (P = 0.08); human CG increased, <2 ± 0.0 vs. 195 ± 16 U/L (P < 0.0001); estradiol increased, 359.3 ± 25.9 pmol/L vs. 3491.8 ± 298.3 pmol/L (P < 0.0001); and PRL increased, 0.23 ± 0.02 vs. 0.95 ± 0.06 U/L (P < 0.0001). Because low maternal free T4 and elevated maternal thyroid-stimulating hormone levels during early gestation have been reported to be associated with impaired psychomotor development in the offspring, our findings indicate the need for additional studies in the children of women who where exposed to high levels of estrogens around the time of conception.
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Rapid estrogen increase during in vitro fertilization is associated with increased TBG and increased TSH in treated hypothyroid women.
“Rapid estrogen increase during in vitro fertilization is associated with increased TBG (209), and increased TSH values in treated hypothyroid women (210).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [209]
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References 22 · Cited by 78
Research works printed but not linked: 1
- Delange FM. 1995 Endemic cretinism. In: Braverman LE, Utiger RD, eds. The thyroid, 7th ed. Philadelphia-New York: Lippincott-Raven; 756 -767.
- Authors
- Muller, A. F., Verhoeff, A., Mantel, M. J., de Jong, F. H., & Berghout, A.
- Affiliations
- Departments of Internal Medicine (A.F.M., A.B.), 3075 EA Rotterdam, The Netherlands
- Obstetrics and Gynecology (A.V.), 3075 EA Rotterdam, The Netherlands
- Clinical Chemistry (M.J.M.), Zuiderziekenhuis Rotterdam, 3075 EA Rotterdam, The Netherlands
- Department of Internal Medicine III, University Hospital Dijkzigt (F.H.d.J.), 3015 GD Rotterdam, The Netherlands
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-02-01
- Volume
- 85
- Issue
- 2
- Pages
- 545-548
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2168578069
- Cited by
- 78
- References
- 22
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- controlled ovarian stimulation, free thyroxine, thyroid function, thyroid-stimulating hormone, T4-binding globulin, thyroid peroxidase antibodies, gonadotropins, estradiol, prolactin, human chorionic gonadotropin, in vitro fertilization, thyroid autoimmunity
- MeSH terms
- Adult, Autoantibodies, Estradiol, Female, Gonadotropins, Chorionic Gonadotropin, Humans, Iodide Peroxidase, Gonadotropin-Releasing Hormone, Menotropins, Ovary, Prolactin, Prospective Studies, Stimulation, Chemical, Thyroid Gland, Thyroxine
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