Serum Allopregnanolone Levels in Pregnant Women: Changes during Pregnancy, at Delivery, and in Hypertensive Patients
Abstract
Allopregnanolone is a neuroactive steroid measurable in peripheral circulation. The aim of the present study was to investigate the presence and the possible changes in serum allopregnanolone and progesterone levels in pregnant women during gestation, at delivery, and in patients with chronic hypertension, with or without superimposed preeclampsia. We also evaluated allopregnanolone in cord blood. Three groups of pregnant women were studied: 1) healthy controls followed longitudinally throughout gestation (n = 14); 2) at vaginal or cesarean delivery (n = 66); and 3) with chronic hypertension (n = 12), with (n = 7) or without (n = 5) superimposed preeclampsia. Allopregnanolone and progesterone levels were measured in maternal and cord serum by RIA. In healthy pregnant women, serum allopregnanolone and progesterone levels progressively increased throughout gestation. Whereas no changes were found at vaginal delivery, serum allopregnanolone and progesterone levels were significantly lower at delivery by emergency cesarean section (P < 0.01). Umbilical cord serum allopregnanolone and progesterone levels in emergency cesarean were significantly lower than those found at vaginal delivery (P < 0.01). Patients with chronic hypertension, with or without superimposed severe preeclampsia, showed serum allopregnanolone levels significantly higher than those of healthy women at the same gestational age (P < 0.01). In conclusion, maternal serum allopregnanolone levels increased during norm…
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Dramatic perinatal changes in circulating levels of allopregnanolone are one potential factor affecting GABAergic signaling and postpartum depression development.
“One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”
From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [30]
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- Authors
- Luisi, S., Petraglia, F., Benedetto, C., Nappi, R. E., Bernardi, F., Fadalti, M., Reis, F. M., Luisi, M., & Genazzani, A. R.
- Affiliations
- University of Pisa (IT)
- University of Udine (IT)
- University of Turin (IT)
- University of Pavia (IT)
- National Research Council (IT)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-07
- Volume
- 85
- Issue
- 7
- Pages
- 2429-2433
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2161288077
- Cited by
- 237
- References
- 26
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 11 · 2023: 6 · 2022: 13 · 2021: 14 · 2020: 11 · 2019: 18 · 2018: 8 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 10 · 2012: 9
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- allopregnanolone, neurosteroids, pregnancy, progesterone, umbilical cord blood, emergency cesarean section, vaginal delivery, chronic hypertension, superimposed preeclampsia, blood pressure regulation, maternal serum
- MeSH terms
- Adult, Female, Fetal Blood, Humans, Hypertension, Labor, Obstetric, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnanolone, Progesterone, Time Factors, Delivery, Obstetric
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