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Cited by 3,541Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

Weyer, Christian, Funahashi, Tohru, Tanaka, Sachiyo, Hotta, Kikuko, Matsuzawa, Yuji, Pratley, Richard E., Tataranni, P. Antonio·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.5.7463
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Abstract

Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity, type 2 diabetes, and cardiovascular disease, conditions commonly associated with insulin resistance and hyperinsulinemia. To further characterize the relationship between adiponectinemia and adiposity, insulin sensitivity, insulinemia, and glucose tolerance, we measured plasma adiponectin concentrations, body composition (dual-energy x-ray absorptiometry), insulin sensitivity (M, hyperinsulinemic clamp), and glucose tolerance (75-g oral glucose tolerance test) in 23 Caucasians and 121 Pima Indians, a population with a high propensity for obesity and type 2 diabetes. Plasma adiponectin concentration was negatively correlated with percent body fat (r = -0.43), waist-to-thigh ratio (r = -0.46), fasting plasma insulin concentration (r = -0.63), and 2-h glucose concentration (r = -0.38), and positively correlated with M (r = 0.59) (all P < 0.001); all relations were evident in both ethnic groups. In a multivariate analysis, fasting plasma insulin concentration, M, and waist-to-thigh ratio, but not percent body fat or 2-h glucose concentration, were significant independent determinates of adiponectinemia, explaining 47% of the variance (r(2) = 0.47). Differences in adiponectinemia between Pima Indians and Caucasians (7.2 +/- 2.6 vs. 10.2 +/- 4.3 microg/ml, P < 0.0001) and between Pima Indians with normal, impaired, and diabetic glucose tolerance (7.5 +/- 2.7, 6.1 +/- 2.0, 5.5 +/- 1.6 microg/ml, P < 0.0001) remained significant after adjustment for adiposity, but not after additional adjustment for M or fasting insulin concentration. These results confirm that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to the degree of insulin resistance and hyperinsulinemia than to the degree of adiposity and glucose intolerance.

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Crossref · 10.1210/jcem.86.5.7463

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Metadata

Authors
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A.
Affiliations
  • National Institutes of Health (US)
  • The University of Osaka (JP)
Corresponding author
Weyer, Christian
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-05
Volume
86
Issue
5
Pages
1930-1935
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.5.7463
OpenAlex
W2132681327
Cited by
3,541
References
33
Citations by year
2026: 18 · 2025: 33 · 2024: 44 · 2023: 56 · 2022: 69 · 2021: 92 · 2020: 92 · 2019: 102 · 2018: 101 · 2017: 124 · 2016: 124 · 2015: 132 · 2014: 162 · 2013: 197 · 2012: 186
FWCI
108.62
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
hypoadiponectinemia, adiponectin, obesity, type 2 diabetes, insulin resistance, hyperinsulinemia, Pima Indians, glucose tolerance, fat mass, waist-to-thigh ratio, ethnic differences, adipose tissue hormones
MeSH terms
Adolescent, Adult, Diabetes Mellitus, Type 2, Female, Humans, Hyperinsulinism, Indians, North American, Insulin Resistance, Male, Middle Aged, Obesity, Proteins, Intercellular Signaling Peptides and Proteins, White People, Adiponectin

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