Proof-of-concept application of continuous glucose monitoring data analytics to identify diabetes glucotypes
Open accessAbstract
Abstract Background In this proof-of-concept study, we evaluated if monogenic diabetes resulting from mutations of the HNF-1α gene (HNF1A-MODY) has a distinctive continuous glucose monitoring (CGM) glucotype, in comparison to type 1 diabetes (T1D). Methods Using CGM data from 5 subjects with HNF1A-MODY and 115 subjects with T1D, we calculated multiple glucose metrics, including measures of within- and between-day variability (such as coefficient variation for each hour [CVb_1h]). Results The MODY and T1D cohorts had minimum CVb_1h of 11.3 ± 4.4 and 18.0 ± 4.9, respectively (P = .02) and maximum CVb_1h of 33.9 ± 5.0 and 50.3 ± 10, respectively (P < .001). All subjects with HNF1A-MODY had a minimum %CVb_1h ≤ 17.3% and maximum %CVb_1h ≤ 37.1%. In contrast, only 12 of 115 subjects with T1D had both a minimum and maximum %CVb_1h below these thresholds (P < .001). Conclusion HNF1A- MODY is characterized by a low hourly, between-day glucose variability. CGM-derived glucose metrics may have potential applicability for screening for atypical diabetes phenotypes in the T1D population.
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There are only a few prior reports on continuous glucose monitoring profiles in GCK-MODY and TF-related MODY.
“There are only a few prior reports on CGM profiles in GCK-MODY and TF-related MODY”
From Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young (2026) · cites this paper as [19]
The Discussion (page unavailable) describes the study’s HNF1A-MODY CGM findings and predicts a different pattern for GCK-MODY. Neither that passage nor the passages found by searching for prior reports state how many CGM-profile reports existed for GCK-MODY or transcription-factor-related MODY. (LLM, conf=0.75)
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References 20 · Cited by 7
- Authors
- Steenkamp, D. W., Cheney, M. C., Ju, Z., Rodbard, D., & Wolpert, H. A.
- Affiliations
- Boston University (US)
- Biomedical Informatics Consultants LLC , Potomac, MD , USA
- Corresponding author
- Steenkamp, Devin W
- Venue
- Journal of the Endocrine Society
- Publisher
- The Endocrine Society
- Published
- 2023-03-06
- Volume
- 7
- Issue
- 5
- Pages
- bvad038-bvad038
- ISSN
- 2472-1972 (ISSN-L)
- PMC
- PMC10074392
- OpenAlex
- W4327726236
- Cited by
- 7
- References
- 20
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the Endocrine Society (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Jaeb Center for Health Research
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- continuous glucose monitoring, HNF1A-MODY, monogenic diabetes, type 1 diabetes, glycemic variability, coefficient of variation, diabetes screening
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