The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
New Signaling Pathways for Hormones and Cyclic Adenosine 3',5'-Monophosphate Action in Endocrine Cells
Abstract
The glycoprotein hormones, ACTH, TSH, FSH, and LH regulate diverse functions in endocrine cells. Although cAMP and PKA have long been shown to mediate specific intracellular signaling events including the transcription of specific genes via the CREB-CBP complex, recent observations have indicated that PKA does not account for all of the intracellular targets of cAMP. For example, TSH stimulation of thyroid cell proliferation is not completely blocked by PKA inhibitors. TSH and FSH can stimulate PKB phosphorylation by a PKAindependent but PI3-K/PDK1-dependent pathway. An FSH inducible kinase, Sgk, has recently been shown to be a close relative of PKB. Sgk is also a target of PI3-K-PDK1 pathway, indicating that some effects previously ascribed to PKB may be mediated by this inducible kinase. The identification of novel cAMP-binding proteins that exhibit guanine nucleotide exchange (GEF) activity (cAMP-GEFS; Epacs) has open new doors for cAMP action that include activation of small GTPases such as Rap1a, Rap2, and possibly Ras. These GTPases are known activators of downstream kinase cascades, including p38MAPK and Erk1/2 as well as PI3-K. Thus, FSH and TSH activation of PKB and Sgk may occur via this alternative cAMP pathway that involves cAMP-GEFs and the activation of the PI3-K/PDK1 pathway.
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Cites
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Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
Self-citationPhosphorylation and Activation of p70 s6k by PDK1
Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826
Effects of an Igf1 Gene Null Mutation on Mouse Reproduction
Baker, J., Hardy, M. P., Zhou, J., Bondy, C., Lupu, F., Bellvé, A. R., & Efstratiadis, A. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.7.8813730 · Cited by 674
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Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways
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Identification of Guanine Nucleotide Exchange Factors (GEFs) for the Rap1 GTPase
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Cited by
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms
Lang, F., Böhmer, C., Palmada, M., Seebohm, G., Strutz-Seebohm, N., & Vallon, V. (2006) · Physiological Reviews · doi:10.1152/physrev.00050.2005 · Cited by 689
Oster, H., Damerow, S., Kiessling, S., Jakubcakova, V., Abraham, D., Tian, J., Hoffmann, M. W., & Eichele, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.002 · Cited by 528
Ovulation: New Dimensions and New Regulators of the Inflammatory-Like Response
Richards, J. S., Russell, D. L., Ochsner, S., & Espey, L. L. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.131029 · Cited by 444
Self-citationShimada, M., Hernandez-Gonzalez, I., Gonzalez-Robayna, I., & Richards, J. S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0504 · Cited by 419
Self-citationNovel Signaling Pathways That Control Ovarian Follicular Development, Ovulation, and Luteinization
Richards, J. S. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.195 · Cited by 414
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Metadata
- Authors
- Richards, J. S.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-02-01
- Volume
- 15
- Issue
- 2
- Pages
- 209-218
- ISSN
- 0888-8809 (ISSN-L)
- OpenAlex
- W2005531798
- Cited by
- 368
- References
- 7
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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