The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
An Estrogen Receptor (ER)α Deoxyribonucleic Acid-Binding Domain Knock-In Mutation Provides Evidence for Nonclassical ER Pathway Signaling in Vivo
Open accessAbstract
We created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving the nonclassical ER pathway. Heterozygous nonclassical ER knock-in (NERKI) females are infertile. Their ovaries contain no corpora lutea, reflecting a defect in ovulation, and the stromal cells contain lipid droplets, suggesting altered steroidogenesis. The uteri are enlarged with evidence of cystic endometrial hyperplasia, and the mammary glands are hypoplastic. These phenotypic features indicate differential ER effects on growth and development in various estrogen-responsive tissues. These findings suggest that nonclassical ER signaling pathways play an important physiological role in the development and function of the reproductive system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Hasegawa, T., Zhao, L., Caron, K. M., Majdic, G., Suzuki, T., Shizawa, S., Sasano, H., & Parker, K. L. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.9.0515 · Cited by 263
Caron, K. M., Ikeda, Y., Soo, S.-C., Stocco, D. M., Parker, K. L., & Clark, B. J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9880 · Cited by 243
Estrogen suppresses transcription of lipoprotein lipase gene
Homma, H., Kurachi, H., Nishio, Y., Takeda, T., Yamamoto, T., Adachi, K., Morishige, K.-I., Ohmichi, M., Matsuzawa, Y., & Murata, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11404 · Cited by 209
Cited by
Androgen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623
Palmitoylation-dependent Estrogen Receptor α Membrane Localization: Regulation by 17β-Estradiol
Acconcia, F., Ascenzi, P., Bocedi, A., Spisni, E., Tomasi, V., Trentalance, A., Visca, P., & Marino, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0547 · Cited by 438
Safe, S., & Kim, K. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0103 · Cited by 368
Hamilton, K. J., Hewitt, S. C., Arao, Y., & Korach, K. S. (2017) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.005 · Cited by 336
LESSONS IN ESTROGEN BIOLOGY FROM KNOCKOUT AND TRANSGENIC ANIMALS
Hewitt, S. C., Harrell, J. C., & Korach, K. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.115914 · Cited by 292
Metadata
- Authors
- Jakacka, M., Ito, M., Martinson, F., Ishikawa, T., Lee, E. J., & Jameson, J. L.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-10-01
- Volume
- 16
- Issue
- 10
- Pages
- 2188-2201
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2097004442
- Cited by
- 184
- References
- 4
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An Estrogen Receptor (ER)α Deoxyribonucleic Acid-Binding Domain Knock-In Mutation Provides Evidence for Nonclassical ER Pathway Signaling in Vivo. https://app.cochat.ai/papers/10.1210/me.2001-0174
- The paper
- Jakacka, M., Ito, M., Martinson, F., Ishikawa, T., Lee, E. J., & Jameson, J. L. (2002). An Estrogen Receptor (ER)α Deoxyribonucleic Acid-Binding Domain Knock-In Mutation Provides Evidence for Nonclassical ER Pathway Signaling in Vivo. Molecular Endocrinology. https://doi.org/10.1210/me.2001-0174
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
