A life-long search for the molecular pathways of steroid hormone action
Open accessAbstract
The O'Malley laboratory first showed that estrogen and progesterone act in the nucleus to stimulate synthesis of specific mRNAs (ovalbumin and avidin), coding for their respective inducible proteins. The overall molecular pathway of steroid-receptor-DNA-mRNA-protein-function was then established and provided a coherent foundation for future studies of the impact of estrogen and progesterone receptors on endocrine tissue development, adult function, and in pathologies such as cancer. The lab group went on to: biochemically demonstrate ligand-induced conformational activation of progesterone and estrogen receptors, discover the concept of ligand-independent activation of steroid receptors, discover key steroid receptor coactivator intermediary coactivators for receptor function, and define the role of coactivators/corepressors in selective receptor modulator drug action and in cell homeostasis. This body of work advanced our molecular understanding of the critical role of steroid hormones in normal and abnormal physiology and also generated a base of scientific knowledge that served to further modern hormonal therapy and disease management.
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References 54 · Cited by 124
- Authors
- O’Malley, B. W.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- O’Malley, Bert W.
- ORCID
- O’Malley, Bert W.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2005-06-01
- Volume
- 19
- Issue
- 6
- Pages
- 1402-1411
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2122368744
- Cited by
- 124
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 07857, HD 08188)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- steroid hormone action, estrogen receptor, progesterone receptor, nuclear receptor signaling, ligand-independent receptor activation, transcriptional coactivator, corepressors, ovalbumin, avidin, mRNA induction, hormone therapy
- MeSH terms
- Animals, Endocrinology, Hormones, Humans, Models, Biological, Receptors, Estrogen, Receptors, Progesterone, RNA, Messenger, Steroids, Signal Transduction, History, 20th Century
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