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Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
Abstract
Serine 167 has been identified by radiolabel and amino acid sequencing as the major estrogen-induced phosphorylation site on the human estrogen receptor (hER) from human MCF-7 mammary carcinoma cells. The phosphorylation of the hER on serine 167 was estrogen-dependent, increasing 4-fold upon estradiol treatment of MCF-7 cells and accounted for almost half of the total [32P]phosphate incorporated into the recombinant hER from Sf9 insect cells and the native hER from MCF-7 cells. Casein kinase II was found to phosphorylate the purified recombinant hER on serine 167 in vitro. In addition, estradiol binding enhanced by 2-fold the phosphorylation of the purified recombinant hER by casein kinase II in vitro. Western blot analysis and [32P]phosphate incorporation confirmed the presence of casein kinase II in Sf9 cells. These results demonstrate that the hER is phosphorylated on serine 167 by casein kinase II in a hormone-dependent manner.
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Cites
Ortí, E., Hu, L. M., & Munck, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53026-x · Cited by 70
Cited by
Bunone, G., Briand, P. A., Miksicek, R. J., & Picard, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00571.x · Cited by 986
Osborne, C. K., Bardou, V., Hopp, T. A., Chamness, G. C., Hilsenbeck, S. G., Fuqua, S. A. W., Wong, J., Allred, D. C., Clark, G. M., & Schiff, R. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.5.353 · Cited by 786
Steroid hormone receptors and their regulation by phosphorylation
WEIGEL, N. L. (1996) · Biochemical Journal · doi:10.1042/bj3190657 · Cited by 354
Cracking the Estrogen Receptor's Posttranslational Code in Breast Tumors
Le Romancer, M., Poulard, C., Cohen, P., Sentis, S., Renoir, J.-M., & Corbo, L. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0016 · Cited by 313
The biological role of estrogen receptors α and β in cancer
Pearce, S. T., & Jordan, V. C. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2003.09.003 · Cited by 311
Metadata
- Authors
- Arnold, S. F.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1994-09-01
- Volume
- 8
- Issue
- 9
- Pages
- 1208-1214
- ISSN
- 0888-8809 (ISSN-L)
- OpenAlex
- W2010042688
- Cited by
- 176
- References
- 1
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnold, S. F. (1994). Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Molecular Endocrinology. https://doi.org/10.1210/me.8.9.1208
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
