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Estrogen Regulation of c-fos Messenger Ribonucleic Acid
Open accessAbstract
Acute administration of 17 beta-estradiol to immature female rats elicits a rapid and striking increase in the size of the uterus. This increase in size to caused by both hypertrophy and hyperplasia in the epithelial, stromal, and myometrial cells in the uterus. Previous studies have shown that induction of mRNA for the epidermal growth factor receptor, the cellular homolog of the erb-B oncogene, occurs early during estrogen-stimulated uterine growth. We report here that estradiol causes a very rapid induction of the mRNA for the cellular oncogene c-fos in immature rat uterus. Steady state levels of c-fos mRNA reach a maximum 3 h after 17 beta-estradiol administration and slowly return to low basal levels in 15 h. Dexamethasone, progesterone, and 5 alpha-dihydrotestosterone had no effect on uterine c-fos mRNA expression. The induction of c-fos mRNA by estrogen was unaffected by the protein synthesis inhibitor puromycin but completely abolished by the RNA synthesis inhibitor actinomycin D.
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Cited by
Dexamethasone attenuates the estradiol-induced increase of IGF-I mRNA in the rat uterus
Sahlin, L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00152-p · Cited by 51
Metadata
- Authors
- Loose-Mitchell, D. S., Chiappetta, C., & Stancel, G. M.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1988-10
- Volume
- 2
- Issue
- 10
- Pages
- 946-951
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2062543439
- Cited by
- 201
- References
- 0
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Loose-Mitchell, D. S., Chiappetta, C., & Stancel, G. M. (1988). Estrogen Regulation of c-fos Messenger Ribonucleic Acid. Molecular Endocrinology. https://doi.org/10.1210/mend-2-10-946
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
