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Molecular Cloning and Characterization of a Rat A1-Adenosine Receptor that is Widely Expressed in Brain and Spinal Cord
Open accessAbstract
An A1-adenosine receptor has been cloned from a rat brain cDNA library using a probe generated by the polymerase chain reaction. The cDNA encodes a protein of 327 amino acids which is 91% identical to a recently cloned dog A1-adenosine receptor (RDC7). Expression of the rat cDNA in COS-6M and NIH 3T3 cells resulted in ligand binding and functional activity characteristics of an A1-adenosine receptor that is coupled to inhibition of adenylyl cyclase. Examination of the distribution of A1-adenosine receptor mRNA by Northern blot analysis showed that it is highly expressed in brain, spinal cord, testis, and white adipose tissue. In situ hybridization studies revealed an extensive hybridization pattern in the central nervous system, with high levels in cerebral cortex, hippocampus, cerebellum, thalamus, brainstem, and spinal cord. The cloned A1-adenosine receptor may thus mediate many of the modulatory actions of adenosine in neural and endocrine systems.
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Cited by
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
Self-citationMolecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
Zhou, Q. Y., Li, C., Olah, M. E., Johnson, R. A., Stiles, G. L., & Civelli, O. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7432 · Cited by 658
Synaptic Control of Motoneuronal Excitability
Rekling, J. C., Funk, G. D., Bayliss, D. A., Dong, X.-W., & Feldman, J. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.2.767 · Cited by 607
Caffeine as a psychomotor stimulant: mechanism of action
Fisone, G., Borgkvist, A., & Usiello, A. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-3269-3 · Cited by 538
Metadata
- Authors
- Reppert, S. M., Weaver, D. R., Stehle, J. H., & Rivkees, S. A.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-08
- Volume
- 5
- Issue
- 8
- Pages
- 1037-1048
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2107747076
- Cited by
- 336
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Molecular Cloning and Characterization of a Rat A1-Adenosine Receptor that is Widely Expressed in Brain and Spinal Cord. https://app.cochat.ai/papers/10.1210/mend-5-8-1037
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- Reppert, S. M., Weaver, D. R., Stehle, J. H., & Rivkees, S. A. (1991). Molecular Cloning and Characterization of a Rat A1-Adenosine Receptor that is Widely Expressed in Brain and Spinal Cord. Molecular Endocrinology. https://doi.org/10.1210/mend-5-8-1037
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
