Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein Family

Manna, Pulak R.; Dyson, Matthew T.; Eubank, Darrell W.; Clark, Barbara J.; Lalli, Enzo; Sassone-Corsi, Paolo; Zeleznik, Anthony J.; Stocco, Douglas M.

doi:10.1210/mend.16.1.0759

Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein Family

The mitochondrial phosphoprotein, the steroidogenic acute regulatory (StAR) protein, is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells through cAMP-dependent pathways. In many cases transcriptional induction by cAMP is mediated through the interactio…