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Cited by 304Proteins in Food SystemsFatty Acid Research and HealthDrug Solubulity and Delivery Systems

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Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products

Sek, Leab, Porter, Christopher J H, Kaukonen, Ann Marie, Charman, William N·2002·Journal of Pharmacy and Pharmacology
DOI 10.1211/0022357021771896
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Abstract

An evaluation of the in-vitro digestion profile and phase behaviour of the common formulation lipids Miglyol 812 (medium chain triglyceride, MCT), Capmul MCM (C8/C10 monoglyceride/ diglyceride mixture), soybean oil (long chain triglyceride, LCT) and Maisine 35-1 (C18 monoglyceride/diglyceride mixture), is described. Experiments were conducted using titrimetric, high-performance thin-layer chromatographic (HPTLC) and ultracentrifugational techniques under model fasted and post-prandial intestinal conditions. The rate and extent of digestion of the medium chain lipids was greater than the corresponding long chain lipids, and independent of bile salt concentration, with complete conversion to monoglyceride and fatty acid occurring after 30 min digestion. The long chain lipid digests separated into an oily phase (containing undigested triglyceride and diglyceride), an aqueous phase (containing bile salt, fatty acid and monoglyceride) and a pellet phase (containing approximately 5 mm of fatty acid, presumably as an insoluble soap) after ultracentrifugation. Higher proportions of long chain fatty acid and monoglyceride were dispersed into the aqueous phase with increasing bile salt concentrations. In contrast, medium chain lipolytic products separated only into an aqueous phase and a pellet fraction in a bile-salt-independent manner. The digestion of both the C8/C10 and C18 monoglyceride/diglyceride lipid mixtures was more rapid than the corresponding triglyceride, especially at ea…

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Research works printed but not linked: 36

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Metadata

Authors
Sek, L., Porter, C. J. H., Kaukonen, A. M., & Charman, W. N.
Affiliations
Monash University (AU)
ORCID
Venue
Journal of Pharmacy and Pharmacology
Publisher
Oxford University Press (OUP)
Published
2002-01-01
Volume
54
Issue
1
Pages
29-41
ISSN
  • 0022-3573 (ISSN-L)
  • 2042-7158
DOI
10.1211/0022357021771896
OpenAlex
W1979049827
Cited by
304
References
1
Citations by year
2026: 4 · 2025: 13 · 2024: 11 · 2023: 12 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 17 · 2018: 22 · 2017: 14 · 2016: 19 · 2015: 21 · 2014: 15 · 2013: 16 · 2012: 19
FWCI
9.13
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Pharmacy and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
in vitro digestion, medium-chain triglycerides, long-chain triglycerides, lipolysis, phase behavior, bile salts, monoglycerides, diacylglycerol, fatty acids, lipid-based formulations, Miglyol 812, Capmul MCM, soybean oil, digestion kinetics
MeSH terms
Caprylates, Chromatography, Thin Layer, Digestion, Glycerides, Lipolysis, Models, Biological, Soybean Oil, Structure-Activity Relationship, Triglycerides

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