The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The use of hypromellose in oral drug delivery
Abstract
Hypromellose, formerly known as hydroxypropylmethylcellulose (HPMC), is by far the most commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. This review provides a current insight into hypromellose and its applicability to hydrophilic matrices in order to highlight the basic parameters that affect its performance. Topics covered include the chemical, thermal and mechanical properties of hypromellose, hydration of the polymer matrices, the mechanism of drug release and the influence of tablet geometry on drug-release rate. The inclusion of drug-release modifiers within hypromellose matrices, the effects of dissolution media and the influence of both the external environment and microenvironment pH within the gel matrix on the properties of the polymer are also discussed.
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Citations
Cites
Higuchi, T. (1963) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600521210 · Cited by 4,884
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)
Siepmann, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00112-0 · Cited by 2,613
Intraluminal pH of the human gastrointestinal tract.
Fallingborg, J. (1999) · PubMed · Cited by 630
Thermal gelation properties of methyl and hydroxypropyl methylcellulose
Sarkar, N. (1979) · Journal of Applied Polymer Science · doi:10.1002/app.1979.070240420 · Cited by 512
Siepmann, J., Kranz, H., Bodmeier, R., & Peppas, N. A. (1999) · Pharmaceutical Research · doi:10.1023/a:1018914301328 · Cited by 365
Optimisation of floating matrix tablets and evaluation of their gastric residence time
Baumgartner, S., Kristl, J., Vrečer, F., Vodopivec, P., & Zorko, B. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00378-6 · Cited by 309
States of Water Associated with Solids
Zografi, G. (1988) · Drug Development and Industrial Pharmacy · doi:10.3109/03639048809151997 · Cited by 274
Ford, J. L., Rubinstein, M. H., McCaul, F., Hogan, J. E., & Edgar, P. J. (1987) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(87)90172-4 · Cited by 269
Self-citationDrug Release from Compressed Hydrophilic Matrices
Lapidus, H., & Lordi, N. G. (1968) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600570803 · Cited by 258
Bettini, R., Catellani, P. L., Santi, P., Massimo, G., Peppas, N. A., & Colombo, P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00366-7 · Cited by 236
Cited by
Azad, M. A., Olawuni, D., Kimbell, G., Badruddoza, A. Z. M., Hossain, M. S., & Sultana, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020124 · Cited by 356
L-arginine increases postprandial circulating GLP-1 and PYY levels in humans
Amin, A., Neophytou, C., Thein, S., Martin, N. M., Alamshah, A., Spreckley, E., Bloom, S. R., & Murphy, K. G. (2018) · Obesity · doi:10.1002/oby.22323 · Cited by 29
Metadata
- Authors
- Li, C. L., Martini, L. G., Ford, J. L., & Roberts, M.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-01
- Volume
- 57
- Issue
- 5
- Pages
- 533-546
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2001465846
- Cited by
- 340
- References
- 34
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, C. L., Martini, L. G., Ford, J. L., & Roberts, M. (2005). The use of hypromellose in oral drug delivery. Journal of Pharmacy and Pharmacology. https://doi.org/10.1211/0022357055957
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
