Body mass index and incidence of dementia: The PAQUID study
Abstract
To study the relationship between body mass index (BMI) and risk of dementia, a cohort of 3,646 individuals aged > or =65 years living at home and without cognitive disorders at baseline were followed up for 8 years (the PAQUID [Personnes Agées Quid] Study). Subjects with a BMI < 21 had an increased risk of developing dementia as compared with subjects whose BMI was between 23 and 26 (odds ratio = 1.48, 95% CI = 1.08 to 2.04). However, when individuals who developed dementia early during the follow-up were excluded from the analysis, this relationship was no longer significant. A low BMI does not in itself seem to be a risk factor for dementia.
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The evidence relating adiposity in old age to Alzheimer's disease is conflicting.
“The evidence relating adiposity in old age to Alzheimer’s disease is conflicting.”
From Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease (2008) · cites this paper as Nourhashemi et al., 2003
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References 10 · Cited by 193
- Authors
- Nourhashémi, F., Deschamps, V., Larrieu, S., Letenneur, L., Dartigues, J.-F., & Barberger-Gateau, P.
- Affiliations
- From the Service de Médecine Interne et de Gérontologie Clinique (Dr. Nourhashémi), CHU Purpan-Casselardit, Toulouse; and INSERM 330 (Drs. Deschamps, Letenneur, Dartigues, and Barberger-Gateau, and S. Larrieu), Université Victor Segalen, Bordeaux, France.
- Inserm (FR)
- Venue
- Neurology
- Published
- 2003-01-14
- Volume
- 60
- Issue
- 1
- Pages
- 117-119
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2053937456
- Cited by
- 193
- References
- 10
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 14 · 2013: 11 · 2012: 17
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- body mass index, dementia, dementia risk, underweight, older adults, PAQUID cohort, obesity
- MeSH terms
- Aged, Dementia, Female, Follow-Up Studies, France, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Risk, Risk Factors, Thinness, Cohort Studies, Body Mass Index, Incidence, Logistic Models, Proportional Hazards Models, Odds Ratio, Risk Assessment
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