Parkinson’s disease risks associated with dietary iron, manganese, and other nutrient intakes
Abstract
BACKGROUND: Dietary influences on oxidative stress have been thought to play important role in the etiology of PD. OBJECTIVE: To examine associations of PD with dietary nutrients, including minerals, vitamins, and fats. METHODS: A population-based case-control study was conducted among newly diagnosed case (n = 250) and control subjects (n = 388) identified between 1992 and 2002 from enrollees of the Group Health Cooperative health maintenance organization in western Washington state. Controls were frequency matched to cases on sex and age. In-person interviews elicited data on food frequency habits during most of adult life. Nutrient intakes were calculated and analyzed by adjusting each person's nutrient intake by their total energy intake (the nutrient density technique). RESULTS: Subjects with an iron intake in the highest quartile compared with those in the lowest quartile had an increased risk of PD (odds ratio = 1.7, 95% CI: 1.0, 2.7, trend p = 0.016). There was an apparent joint effect of iron and manganese; dietary intake above median levels of both together conferred a nearly doubled risk compared with lower intakes of each nutrient (odds ratio = 1.9, 95% CI: 1.2, 2.9). No strong associations were found for either antioxidants or fats. CONCLUSION: A high intake of iron, especially in combination with high manganese intake, may be related to risk for PD.
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Men were found to have some risk with the use of supplemental iron.
“Men were found to have some risk with the use of supplemental iron.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Powers et al., 2003
Risk for Parkinson's disease was higher among those whose diets contained large amounts of non-heme iron primarily derived from fortified grains and cereals.
“The risk for Parkinson's disease was higher among those whose diets contained large amounts of non-heme iron primarily derived from fortified grains and cereals.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Powers et al., 2003
Investigators did not find an association between heme iron and Parkinson's disease risk.
“The investigators did not find an association with heme iron ( Logroscino et al., 1998;Gorell et al., 1999;Powers et al., 2003).”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Powers et al., 2003
In a prospective study on a cohort of 47,406 men and 76,947 women, risk of Parkinson's disease was greater for persons whose vitamin C intakes were lower.
“The prospective study on a cohort of 47,406 men and 76,947 women indicated that risk was greater for persons whose vitamin C intakes were lower.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Powers et al., 2003
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References 36 · Cited by 268
- Authors
- Powers, K. M., Smith-Weller, T., Franklin, G. M., Longstreth, W. T., Swanson, P. D., & Checkoway, H.
- Affiliations
- University of Washington (US)
- From the Departments of Environmental Health (Drs. Franklin and Checkoway and K.M. Powers and T. Smith-Weller), Neurology (Drs. Franklin, Longstreth, and Swanson), and Epidemiology (Drs. Longstreth and Checkoway), University of Washington School of Medicine, Seattle.
- ORCID
- Franklin, G.M.
- Venue
- Neurology
- Published
- 2003-06-10
- Volume
- 60
- Issue
- 11
- Pages
- 1761-1766
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1996988384
- Cited by
- 268
- References
- 36
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 16 · 2021: 14 · 2020: 12 · 2019: 4 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 14 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- National Institute of Environmental Health Sciences (ES04696, ES 10750, P42ES004696, R01ES010750)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- Parkinson's disease, dietary iron, dietary manganese, nutrient intake, oxidative stress, antioxidant vitamins, dietary fat, disease risk factors, food frequency, Group Health Cooperative
- MeSH terms
- Adult, Aged, Antioxidants, Diet, Fats, Female, Humans, Male, Manganese, Middle Aged, Minerals, Parkinson Disease, Risk Factors, Vitamins, Case-Control Studies, Iron, Dietary
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