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Cited by 197

The DOI matches its Crossref record.

Gestation-induced changes in lamotrigine pharmacokinetics: A monotherapy study

de Haan, G -J., Edelbroek, P., Segers, J., Engelsman, M., Lindhout, D., Dévilé-Notschaele, M., Augustijn, P.·2004·Neurology
DOI 10.1212/01.wnl.0000133213.10244.fd
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Abstract

The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level-to-dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjustments are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.

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Metadata

Authors
de Haan, G. J., Edelbroek, P., Segers, J., Engelsman, M., Lindhout, D., Dévilé-Notschaele, M., & Augustijn, P.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-08-10
Volume
63
Issue
3
Pages
571-573
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000133213.10244.fd
OpenAlex
W2134200996
Cited by
197
References
0
FWCI
14.28
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Gestation-induced changes in lamotrigine pharmacokinetics: A monotherapy study. https://app.cochat.ai/papers/10.1212/01.wnl.0000133213.10244.fd
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de Haan, G. J., Edelbroek, P., Segers, J., Engelsman, M., Lindhout, D., Dévilé-Notschaele, M., & Augustijn, P. (2004). Gestation-induced changes in lamotrigine pharmacokinetics: A monotherapy study. Neurology. https://doi.org/10.1212/01.wnl.0000133213.10244.fd

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.