Is fatigue an independent and persistent symptom in patients with Parkinson disease?
Abstract
Objective To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. Methods In 1993, 233 patients with PD were included in a community-based study of fatigue and followed prospectively over 8 years. Fatigue was measured by a combination of a seven-point scale and parts of the Nottingham Health Profile (NHP) at baseline and after 4 and 8 years. In addition, the Fatigue Severity Scale (FSS) was used to evaluate fatigue in 2001. Population-averaged logistic regression models for correlated data were performed to study the relationship between fatigue and various demographic and clinical variables. Results In patients who were followed throughout the 8-year study period, fatigue increased from 35.7% in 1993 to 42.9% in 1997 and 55.7% in 2001. Fatigue was related to disease progression, depression, and excessive daytime sleepiness (EDS). However, the prevalence of fatigue in patients without depression and EDS remained high and increased from 32.1% to 38.9% during the study period. For about 44% of the patients with fatigue the presence of this symptom varied during the study period, as it was persistent in 56% of the patients with fatigue. Conclusions The authors confirmed the high prevalence of mental fatigue in patients with Parkinson disease (PD). Fatigue is related to other non-motor features such as depression and excessive dayt…
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Previous studies have identified increased motor and cognitive fatigue in persons with PD.
“Previous studies have identified increased motor (Friedman & Friedman, 1993; van Hilten et al., 1993) and cognitive fatigue (Alves et al., 2004; Dashtipour et al., 2015) in persons with PD.”
From Perception of Physical Demand, Mental Demand, and Performance: A Comparison of Two Voice Interventions for Parkinson's Disease (2022) · cites this paper as Alves et al., 2004
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- Authors
- Alves, G., Wentzel-Larsen, T., & Larsen, J. P.
- Affiliations
- Haukeland University Hospital (NO)
- From the Department of Neurology (Drs. Alves and Larsen), Rogaland Central Hospital, Stavanger; The Norwegian Centre for Movement Disorders (Drs. Alves and Larsen), Stavanger; and Centre for Clinical Research (T. Wentzel-Larsen), Haukeland University Hospital, Bergen, Norway.
- ORCID
- Alves, G.
- Venue
- Neurology
- Published
- 2004-11-23
- Volume
- 63
- Issue
- 10
- Pages
- 1908-1911
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2116211649
- Cited by
- 215
- References
- 21
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 13 · 2016: 17 · 2015: 10 · 2014: 10 · 2013: 16 · 2012: 9
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- Parkinson's disease, mental fatigue, fatigue prevalence, persistent fatigue, non-motor symptoms, depression, excessive daytime sleepiness, disease progression, Fatigue Severity Scale, Nottingham Health Profile
- MeSH terms
- Aged, Aged, 80 and over, Chronic Disease, Depression, Fatigue, Mental Fatigue, Female, Follow-Up Studies, Humans, Male, Middle Aged, Norway, Parkinson Disease, Prospective Studies, Severity of Illness Index, Cohort Studies, Comorbidity, Disease Progression
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