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Pattern of glucose hypometabolism in frontotemporal dementia with motor neuron disease
Abstract
Frontotemporal dementia (FTD) often coexists with motor neuron disease (MND). To characterize glucose hypometabolism in patients with FTD with MND (FTD/MND), the authors compared the glucose metabolism of 8 patients with FTD/MND with that of 29 patients with FTD. All of the patients with FTD/MND showed glucose hypometabolism only in the frontal area, whereas most patients with FTD had hypometabolism in the frontal and temporal areas. FTD/MND also showed a more symmetric pattern of glucose hypometabolism than FTD.
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Reduced metabolism of glucose is a feature of the brain in Alzheimer disease and FTD, aggravating the deterioration of neuronal functions.
“Reduced metabolism of glucose is also a feature of the brain in Alzheimer disease40–42 and FTD43,44, aggravating the deterioration of neuronal functions.”
From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [43]
Both Alzheimer disease and FTD are characterized by hypometabolism of glucose.
“As both dementias are characterized by a hypometabolism of glucose40–44,72, deteriorating lipoprotein receptor functions of sortilin in the ageing brain may well aggravate deficits in neuronal energy production in the older population.”
From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [43]
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Research works printed but not linked: 10
- 10.1136/jnnp.53.1.23 · DOI
- 10.1136/jnnp.58.5.541 · DOI
- 10.1212/01.WNL.0000078928.20107.52 · DOI
- 10.1016/S0022-510X(99)00188-4 · DOI
- 10.1212/WNL.51.6.1546 · DOI · Paper page
- 10.1111/j.1552-6569.2004.tb00235.x · DOI
- Jeong Y Cho SS Park JM et al. FDG PET findings in frontotemporal dementia: an SPM analysis of 29 patients. J Nucl Med (in press).
- Ishii K, Sakamoto S, Sasaki M, et al. Cerebral glucose metabolism in patients with frontotemporal dementia. J Nucl Med 1998;39:1875–1878.
- 10.1159/000052084 · DOI
- Salmon E, Garraux G, Delbeuck X, et al. Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia. Neuroimage 2003;20:435–440.
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Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics
Whitwell, J. L., Weigand, S. D., Boeve, B. F., Senjem, M. L., Gunter, J. L., DeJesus-Hernandez, M., Rutherford, N. J., Baker, M., Knopman, D. S., Wszolek, Z. K., et al. (2012) · Brain · doi:10.1093/brain/aws001 · Cited by 397
Greda, A. K., Gomes, J. P., Schmidt-Krueger, V., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.-M., Telugu, N. S., Cömert, C., Kirwan, J., Kunz, S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01389-5 · Cited by 21
Metadata
- Authors
- Jeong, Y., Park, K. C., Cho, S. S., Kim, E. J., Kang, S. J., Kim, S. E., Kang, E., & Na, D. L.
- Affiliations
- From the Department of Neurology (Drs. Jeong, Park, Kim, and Na, S.J. Kang), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Nuclear Medicine (Dr. Kim and S.S. Cho), Seoul National University Bundang Hospital, Seongnam, Korea; and Department of Nuclear Medicine (Dr. E. Kang), Seoul National University, Seoul, Korea.
- Venue
- Neurology
- Published
- 2005-02-22
- Volume
- 64
- Issue
- 4
- Pages
- 734-736
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 50
- References
- 0
- Language
- en
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