Axonal damage markers in cerebrospinal fluid are increased in ALS
Abstract
Objective To test whether biomarkers for axonal degeneration correlated with clinical subtypes and were of use in predicting progression of ALS. Methods Patients with ALS (n = 69), patients with Alzheimer disease (AD; n = 73), and age-matched controls (n = 33) were included in this prospective study. CSF levels of tau protein and neurofilaments (NfHSMI35) were measured using ELISA. In 49 patients with ALS, follow-up data were available (median follow-up 7 months). Results CSF levels of NfHSMI35 were five times higher in patients with ALS (1.7 ng/mL) than in controls (0.3 ng/mL, p Conclusions The authors propose that axonal damage markers in CSF may discriminate between subtypes of ALS and that they could be used as markers for therapeutic trials. CSF NfH was superior to tau in these discriminations.
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Increased Qalb values were found in 40% of all studied amyotrophic lateral sclerosis cases (55/138 from 4 independent studies).
“increased Qalb values were found in 40% of all studied ALS cases (i.e., 55/138 from 4 independent studies) (23, 79, 407, 525)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [79]
A subset of amyotrophic lateral sclerosis patients shows increased Qalb ratio and elevated CSF levels of several blood-derived proteins.
“A subset of ALS patients shows increased Qalb ratio and elevated CSF levels of several blood-derived proteins (79, 652).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [79]
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- Authors
- Brettschneider, J., Petzold, A., Süßmuth, S. D., Ludolph, A. C., & Tumani, H.
- Affiliations
- Universität Ulm (DE)
- Venue
- Neurology
- Published
- 2006-03-28
- Volume
- 66
- Issue
- 6
- Pages
- 852-856
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2026158140
- Cited by
- 261
- References
- 32
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 14 · 2023: 4 · 2022: 19 · 2021: 16 · 2020: 14 · 2019: 17 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 21 · 2013: 14 · 2012: 19
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyotrophic lateral sclerosis, cerebrospinal fluid biomarkers, axonal injury, neurofilament H, tau protein, disease progression prediction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Axons, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nerve Degeneration, Cohort Studies, Biomarkers, tau Proteins, Neurofilament Proteins
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