The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Acute disseminated encephalomyelitis
Abstract
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory disorder of the CNS characterized by a widespread demyelination that predominantly involves the white matter of the brain and spinal cord. The condition is usually precipitated by a viral infection or vaccination. The presenting features include an acute encephalopathy with multifocal neurologic signs and deficits. Children are preferentially affected. In the absence of specific biologic markers, the diagnosis of ADEM is still based on the clinical and radiologic features. Although ADEM usually has a monophasic course, recurrent or multiphasic forms have been reported, raising diagnostic difficulties in distinguishing these cases from multiple sclerosis (MS). The International Pediatric MS Study Group proposes uniform definitions for ADEM and its variants. We discuss some of the difficulties in the interpretation of available literature due to the different terms and definitions used. In addition, this review summarizes current knowledge of the main aspects of ADEM, including its clinical and radiologic diagnostic features, epidemiology, pathogenesis, and outcome. An overview of ADEM treatment in children is provided. Finally, the controversies surrounding pediatric MS and ADEM are addressed.
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Citations
Cites
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H., & Miller, S. D. (2005) · Nature Medicine · doi:10.1038/nm1202 · Cited by 694
Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts
DeLuca, G. C. (2004) · Brain · doi:10.1093/brain/awh118 · Cited by 255
Cited by
Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562
MRI characteristics of neuromyelitis optica spectrum disorder: An international update
Kim, H. J., Paul, F., Lana-Peixoto, M. A., Tenembaum, S., Asgari, N., Palace, J., Klawiter, E. C., Sato, D. K., de Seze, J., Wuerfel, J., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001367 · Cited by 664
Self-citationAcute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome
Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S., & Belman, A. L. (2016) · Neurology · doi:10.1212/wnl.0000000000002825 · Cited by 462
Self-citationWallner-Blazek, M., Rovira, A., Fillipp, M., Rocca, M. A., Miller, D. H., Schmierer, K., Frederiksen, J., Gass, A., Gama, H., Tilbery, C. P., et al. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6918-y · Cited by 84
Vincenti, I., Page, N., Steinbach, K., Yermanos, A., Lemeille, S., Nunez, N., Kreutzfeldt, M., Klimek, B., Di Liberto, G., Egervari, K., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl6058 · Cited by 70
Metadata
- Authors
- Tenembaum, S., Chitnis, T., Ness, J., & Hahn, J. S.
- Venue
- Neurology
- Published
- 2007-04-17
- Volume
- 68
- Issue
- 16_suppl_2
- Pages
- S23-36
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W4232721053
- Cited by
- 631
- References
- 2
- FWCI
- 23.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tenembaum, S., Chitnis, T., Ness, J., & Hahn, J. S. (2007). Acute disseminated encephalomyelitis. Neurology. https://doi.org/10.1212/01.wnl.0000259404.51352.7f
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