Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis?
Abstract
Background To evaluate whether oligoclonal bands (OB) add information to MRI in predicting both a second attack and development of disability in patients with clinically isolated syndromes (CIS). Methods From 1995 to 2006, 572 patients with CIS were included in a prospective study. Patients underwent brain MRI and determination of OB within 3 months of first attack. The number and location of lesions and presence of OB were studied. We analyzed time to second attack and to Expanded Disability Status Scale 3.0 according to number of Barkhof criteria (BC) and the presence or absence of OB. Results We studied 415 (73%) patients with CIS with both baseline MRI and determination of OB. Patients were followed for a mean of 50 months (SD 31). Compared to the reference group with 0 BC at baseline MRI, patients with one to two BC showed a hazard ratio (HR) for conversion to CDMS of 3.8 (2.0 to 7.2) and patients with three to four BC of 8.9 (4.8 to 16.4). Of the total cohort, OB were positive in 61% of the patients. However, broken down by MRI group, OB were positive in 31% of those with no BC; 69% of those with one to two BC; and 85% of those with three or four BC. The presence of OB increased the risk of a second relapse (HR 1.7; 1.1 to -2.7) independently of baseline MRI but did not modify the development of disability. Conclusions Presence of oligoclonal bands doubles the risk for having a second attack, independently of MRI, but does not seem to influence the development of disabi…
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Multiple studies provide evidence that in adult patients with CIS, CSF OCBs are an independent predictor of the risk of a second attack when controlling for demographic, clinical, treatment, and MRI variables.
“Multiple studies provide evidence that in adult patients with CIS, CSF OCBs are an independent predictor of the risk of a second attack when controlling for demographic, clinical, treatment, and MRI variables. 61-69”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [66]
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References 22 · Cited by 345
- Authors
- Tintoré, M., Rovira, A., Río, J., Tur, C., Pelayo, R., Nos, C., Téllez, N., Perkal, H., Comabella, M., Sastre-Garriga, J., & Montalban, X.
- Affiliations
- From CENTRE: Unit of Clinical Neuroimmunology (Department of Neurology) (M.T., J.R., C.T., R.P., C.N., N.T., H.P., M.C., J.S.-G., X.M.), Magnetic Resonance Unit (Department of Radiology) (A.R.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
- Universitat Autònoma de Barcelona (ES)
- Venue
- Neurology
- Published
- 2008-03-25
- Volume
- 70
- Issue
- 13_part_2
- Pages
- 1079-1083
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2088302755
- Cited by
- 345
- References
- 22
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 22 · 2019: 14 · 2018: 28 · 2017: 24 · 2016: 22 · 2015: 30 · 2014: 26 · 2013: 27 · 2012: 27
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- oligoclonal bands, clinically isolated syndrome, multiple sclerosis, brain MRI, Barkhof criteria, second relapse, disability progression, Expanded Disability Status Scale, risk prediction
- MeSH terms
- Adult, Brain, Disability Evaluation, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Predictive Value of Tests, Prognosis, Prospective Studies, Recurrence, Risk Factors, Severity of Illness Index, Cohort Studies, Biomarkers, Disease Progression, Oligoclonal Bands
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