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Cited by 102Advanced Neuroimaging Techniques and ApplicationsMultiple Sclerosis Research StudiesGlaucoma and retinal disorders

Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities

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Naismith, R. T., Xu, J., Tutlam, N. T., Snyder, A., Benzinger, T., Shimony, J., Shepherd, J., Trinkaus, K. +2 more·2009·Neurology
DOI 10.1212/01.wnl.0000335766.22758.cdPMC PMC2672917
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Abstract

OBJECTIVE: To determine the potential of directional diffusivities from diffusion tensor imaging (DTI) to predict clinical outcome of optic neuritis (ON), and correlate with vision, optical coherence tomography (OCT), and visual evoked potentials (VEP). METHODS: Twelve cases of acute and isolated ON were imaged within 30 days of onset and followed prospectively. Twenty-eight subjects with a remote clinical history of ON were studied cross-sectionally. Twelve healthy controls were imaged for comparison. DTI data were acquired at 3T with a surface coil and 1.3 x 1.3 x 1.3 mm(3) isotropic voxels. RESULTS: Normal DTI parameters (mean +/- SD, microm(2)/ms) were axial diffusivity = 1.66 +/- 0.18, radial diffusivity = 0.81 +/- 0.26, apparent diffusion coefficient (ADC) = 1.09 +/- 0.21, and fractional anisotropy (FA) = 0.43 +/- 0.15. Axial diffusivity decreased up to 2.5 SD in acute ON. The decrease in axial diffusivity at onset correlated with visual contrast sensitivity 1 month (r = 0.59) and 3 months later (r = 0.65). In three subjects followed from the acute through the remote stage, radial diffusivity subsequently increased to > 2.5 SD above normal, as did axial diffusivity and ADC. In remote ON, radial diffusivity correlated with OCT (r = 0.81), contrast sensitivity (r = 0.68), visual acuity (r = 0.56), and VEP (r = 0.54). CONCLUSION: In acute and isolated demyelination, axial diffusivity merits further investigation as a predictor of future clinical outcome. Diffusion parameters are dynamic in acute and isolated optic neuritis, with an initial acute decrease in axial diffusivity. In remote disease, radial diffusivity correlates with functional, structural, and physiologic tests of vision.

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  • In AD, AxD measures increase relative to controls.

    “In AD, AxD measures increase relative to controls, while we found reductions in measures of AxD 42.”

    From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [42]

    The Results (Acute ON; page unavailable) report increased axial diffusivity relative to normal after one year in three people with optic neuritis, not in Alzheimer’s disease (AD). A search for AD and axial diffusivity relative to controls found no passage addressing the attributed claim. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Naismith, R. T., Xu, J., Tutlam, N. T., Snyder, A., Benzinger, T., Shimony, J., Shepherd, J., Trinkaus, K., Cross, A. H., & Song, S.-K.
Affiliations
Washington University in St. Louis (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-02-17
Volume
72
Issue
7
Pages
589-594
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000335766.22758.cd
PMC
PMC2672917
OpenAlex
W2092631976
Cited by
102
References
1
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 8
FWCI
9.50
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k23ns052430-03, UL1TR000448)
  • National Institute of Neurological Disorders and Stroke (K23NS052430, P30NS048056)
  • National Center for Research Resources (K12 RR02324902, K12RR023249, UL1RR024992, K24RR017100)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords
optic neuritis, diffusion tensor imaging, axial diffusivity, radial diffusivity, apparent diffusion coefficient, fractional anisotropy, visual outcome prediction, contrast sensitivity, visual acuity, visual evoked potentials, optical coherence tomography, demyelination
MeSH terms
Adult, Cross-Sectional Studies, Diffusion, Evoked Potentials, Visual, Female, Humans, Male, Middle Aged, Optic Neuritis, Prospective Studies, Contrast Sensitivity, Diffusion Magnetic Resonance Imaging, Young Adult

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