Sleep duration and risk of fatal and nonfatal stroke: A prospective study and meta-analysis
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OBJECTIVE: To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis. METHODS: The prospective study included 9,692 stroke-free participants aged 42-81 years from the European Prospective Investigation into Cancer-Norfolk cohort. Participants reported sleep duration in 1998-2000 and 2002-2004, and all stroke cases were recorded until March 31, 2009. For the meta-analysis, we searched Ovid Medline, EMBASE, and the Cochrane Library for prospective studies published until May 2014, and pooled effect estimates using a weighted random-effect model. RESULTS: After 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep was significantly associated with an increased risk of stroke (hazard ratio [HR] = 1.46 [95% confidence interval (CI) 1.08, 1.98]) after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep was smaller (and not statistically significant) (HR = 1.18 [95% CI 0.91, 1.53]). There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep. These were compatible with the pooled HRs from an updated meta-analysis, which were 1.15 (1.07, 1.24) and 1.45 (1.30, 1.62) for short and long sleep duration, respectively. CONCLUSIONS: This prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population.
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Long sleep duration is positively linked with the morbidity of stroke.
“Suggestive evidence has shown that long sleep duration is positively linked with the morbidity of stroke (32) and mortality of stroke per 1-h increase in sleep duration (42).”
From Sleep Duration/Quality with Health Outcomes: An Umbrella Review of Meta-Analyses of Prospective Studies (2022) · cites this paper as [32]
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References 40 · Cited by 243
Research works printed but not linked: 1
- [21]Lauderdale D Knutson KL Yan LL Liu K Rathouz PJ Sleep duration: how well do self-reports reflect objective measures? The CARDIA Sleep Study. Epidemiology 2008; 19: 838– 845. 18854708 PMC2785092
- Authors
- Leng, Y., Cappuccio, F. P., Wainwright, N. W. J., Surtees, P. G., Luben, R., Brayne, C., & Khaw, K.-T.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Leng, Yue
- Venue
- Neurology
- Published
- 2015-03-17
- Volume
- 84
- Issue
- 11
- Pages
- 1072-1079
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4371404
- OpenAlex
- W2135549297
- Cited by
- 243
- References
- 40
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 23 · 2023: 21 · 2022: 17 · 2021: 24 · 2020: 24 · 2019: 24 · 2018: 24 · 2017: 24 · 2016: 26 · 2015: 9
- FWCI
- 41.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (publishedVersion, cc-by)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Funders
- Cancer Research UK (C864/A14136, SP2024–0204)
- National Institute for Health and Care Research (NF-SI-0512-10114, NF-SI-0611-10084)
- University of Warwick
- Economic and Social Research Council (ES/K002910/1)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- sleep duration, stroke, long sleep, short sleep duration, stroke risk, fatal stroke, non-fatal stroke, healthy aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Sleep, Sleep Deprivation, Time Factors, Stroke
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