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Healthy eating and reduced risk of cognitive decline: A cohort from 40 countries
Open accessAbstract
OBJECTIVE: We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease. METHODS: Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel trials of the ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) studies. We measured diet quality using the modified Alternative Healthy Eating Index. Cox proportional hazards regression was used to determine the association between diet quality and risk of ≥3-point decline in Mini-Mental State Examination score, and reported as hazard ratio with 95% confidence intervals with adjustment for covariates. RESULTS: During 56 months of follow-up, 4,699 cases of cognitive decline occurred. We observed lower risk of cognitive decline among those in the healthiest dietary quintile of modified Alternative Healthy Eating Index compared with lowest quintile (hazard ratio 0.76, 95% confidence interval 0.66-0.86, Q5 vs Q1). Lower risk of cognitive decline was consistent regardless of baseline cognitive level. CONCLUSION: We found that higher diet quality was associated with a reduced risk of cognitive decline. Improved diet quality represents an important potential target for reducing the global burden of cognitive decline.
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“A higher diet quality in adult life has been associated with a reduced risk of cognitive decline [82].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [82]
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References 26 · Cited by 85
Metadata
- Authors
- Smyth, A., Dehghan, M., O'Donnell, M., Anderson, C., Teo, K., Gao, P., Sleight, P., Dagenais, G., Probstfield, J. L., Mente, A., Yusuf, S., Yusuf, S., Diaz, R., Piegas, L., Teo, K., Dagenais, G., Cardona, E., Probstfield, J., Weber, M., Young, J., Fagard, R., Mallion, J., Mann, J., Bohm, M., Karatzas, N., Keltai, M., Trimarco, B., Verdecchia, P., Ceremuzynski, L., Budaj, A., Ferreira, R., Chazova, I., Ryden, L., Fodor, G., Commerford, P., Redon, J., Luescher, T., Oto, A., Binbrek, A., Sleight, P., Parkhomenko, A., Jennings, G., Liu, L., Sanderson, J., Lang, C. C., Kim, J.-H., Chen, J.-H., Chaithiraphan, S., Jansky, P., Paolasso, E., Avezum, A., Eber, B., Maggioni, A., Mancia, G., Holwerda, N., Svendsen, T. L., Metsarinne, K., Dickstein, K., & Kwok, B.
- Affiliations
- The George Institute for Global Health (GB)
- From the Population Health Research Institute (A.S., M.D., M.O.D., K.T., P.G., A.M., S.Y.), McMaster University, Hamilton, Canada; Health Research Board Clinical Research Facility (A.S., M.O.D.), National University of Ireland, Galway; The George Institute for Global Health (C.A.), Australia; Nuffield Department of Medicine (P.S.), John Radcliffe Hospital, Oxford, UK; Laval University Heart and Lung Institute (G.D.), Quebec, Canada; and University of Washington (J.L.P.), School of Medicine, Seattle,...
- Ollscoil na Gaillimhe – University of Galway (IE)
- ORCID
- Venue
- Neurology
- Published
- 2015-06-02
- Volume
- 84
- Issue
- 22
- Pages
- 2258-2265
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4456656
- OpenAlex
- W1691381132
- Cited by
- 85
- References
- 26
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 5
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- cognitive decline, diet quality, healthy eating, Alternative Healthy Eating Index, Mini-Mental State Examination, cardiovascular disease, telmisartan, ramipril, dementia prevention, dietary intake
- MeSH terms
- Aged, Cognition Disorders, Double-Blind Method, Feeding Behavior, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Risk Factors, Cohort Studies, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Internationality, Risk Reduction Behavior
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