The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Sudden cardiac arrest in people with epilepsy in the community: Circumstances and risk factors
Open accessAbstract
OBJECTIVE: To ascertain whether characteristics of ventricular tachycardia/fibrillation (VT/VF) differed between people with epilepsy and those without and which individuals with epilepsy were at highest risk. METHODS: We ascertained 18 people with active epilepsy identified in a community-based registry of sudden cardiac arrest (SCA) with ECG-confirmed VT/VF (cases). We compared them with 470 individuals with VT/VF without epilepsy (VT/VF controls) and 54 individuals with epilepsy without VT/VF (epilepsy controls). Data on comorbidity, epilepsy severity, and medication use were collected and entered into (conditional) logistic regression models to identify determinants of VT/VF in epilepsy. RESULTS: In most cases, there was an obvious (10/18) or presumed cardiovascular cause (5/18) in view of preexisting heart disease. In 2 of the 3 remaining events, near-sudden unexpected death in epilepsy (SUDEP) was established after successful resuscitation. Cases had a higher prevalence of congenital/inherited heart disease (17% vs 1%, p = 0.002), and experienced VT/VF at younger age (57 vs 64 years, p = 0.023) than VT/VF controls. VT/VF in cases occurred more frequently at/near home (89% vs 58%, p = 0.009), and was less frequently witnessed (72% vs 89%, p = 0.048) than in VT/VF controls. Cases more frequently had clinically relevant heart disease (50% vs 15%, p = 0.005) and intellectual disability (28% vs 1%, p < 0.001) than epilepsy controls. CONCLUSION: Cardiovascular disease rather than epilepsy characteristics is the main determinant of VT/VF in people with epilepsy in the community. SCA and SUDEP are partially overlapping disease entities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Note that most cases of sudden cardiac arrest in patients with epilepsy are due to cardiovascular disease and not to ictal asystole.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [420]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fisher, R. S., Boas, W. V. E., Blume, W. T., Elger, C. E., Genton, P., Lee, P., & Engel, J. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.66104.x · Cited by 3,678
Beghi, E., Berg, A. T., Carpio, A., Forsgren, L., Hesdorffer, D. C., Hauser, W. A., Malmgren, K., Shinnar, S., Temkin, N. R., Thurman, D. J., et al. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00273_1.x · Cited by 2,301
Cummins, R. O., Chamberlain, D. A., Abramson, N. S., Allen, M. R., Baskett, P. J. F., Becker, L. B., Bossaert, L. L., Delooz, H. H., Dick, W., & Eisenberg, M. S. (1991) · Circulation · doi:10.1161/01.cir.84.2.960 · Cited by 1,669
Sudden unexpected death in epilepsy: current knowledge and future directions
Tomson, T., Nashef, L. A. M., & Ryvlin, P. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70202-3 · Cited by 673
Unifying the definitions of sudden unexpected death in epilepsy
Nashef, L., So, E. L., Ryvlin, P., & Tomson, T. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2011.03358.x · Cited by 632 · cited 2×
“SUDEP was defined as sudden, unexpected, witnessed or unwitnessed, nontraumatic and nondrowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus (seizure duration $30 minutes or seizures without recovery in betw…”
BackgroundThe Epidemiology of the Comorbidity of Epilepsy in the General Population
Gaitatzis, A., Carroll, K., Majeed, A., & Sander, J. W. A. S. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.17504.x · Cited by 607
Self-citationSudden unexpected death in epilepsy: risk factors and potential pathomechanisms
Surges, R., Thijs, R. D., Tan, H. L., & Sander, J. W. A. S. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.118 · Cited by 434
Self-citationSudden cardiac death: epidemiology and risk factors
Adabağ, S., Luepker, R. V., Roger, V. L., & Gersh, B. J. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.3 · Cited by 430
Puranik, R., Chow, C. K., Duflou, J. A., Kilborn, M. J., & McGuire, M. A. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.09.008 · Cited by 376
Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy
Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M., & Ackerman, M. J. (2008) · Neurology · doi:10.1212/01.wnl.0000335760.02995.ca · Cited by 281
Flagged first, then by citations
Cited by
Sorted by citations
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy
Purnell, B. S., Thijs, R. D., & Buchanan, G. F. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01079 · Cited by 67
Self-citation
Metadata
- Authors
- Lamberts, R. J., Blom, M. T., Wassenaar, M., Bardai, A., Leijten, F. S., de Haan, G.-J., Sander, J. W., Thijs, R. D., & Tan, H. L.
- Affiliations
- Leiden University Medical Center (NL)
- From the Stichting Epilepsie Instellingen Nederland (SEIN) (R.J.L., M.W., G.-J.d.H., J.W.S., R.D.T.), Heemstede; Academic Medical Center (M.T.B., A.B., H.L.T.), Amsterdam; University Medical Center Utrecht (M.W., F.S.L.), Netherlands; NIHR University College London Hospitals Biomedical Research Centre (J.W.S., R.D.T.), UCL Institute of Neurology, Queen Square, London; Epilepsy Society (J.W.S., R.D.T.), Chalfont St Peter, UK; and LUMC Leiden University Medical Center (R.D.T.), Leiden, Netherlands.
- ORCID
- Venue
- Neurology
- Published
- 2015-07-21
- Volume
- 85
- Issue
- 3
- Pages
- 212-218
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4516291
- OpenAlex
- W2123562461
- Cited by
- 72
- References
- 35
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 9 · 2015: 5
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (918-86-616)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Keywords
- sudden cardiac arrest, epilepsy, ventricular tachycardia, ventricular fibrillation, sudden unexpected death in epilepsy, congenital heart disease, inherited heart disease, cardiovascular comorbidity, intellectual disability, risk factors, community-based registry
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Cross-Sectional Studies, Epilepsy, Female, Humans, Male, Middle Aged, Prospective Studies, Registries, Residence Characteristics, Risk Factors, Case-Control Studies, Death, Sudden, Cardiac, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
